m-IgG Fc BP-HRP (mouse IgG Fc binding protein-HRP) and m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP) are the preferred secondary detection reagents for connexin 40 Antibody (B-3) for WB applications. These reagents are now offered in bundles with connexin 40 Antibody (B-3) (see ordering information below).
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connexin 40 Antibody (B-3) is a high quality monoclonal connexin 40 antibody (also designated GJA5 antibody, gap junction protein alpha 5 antibody, or CX40 antibody) suitable for the detection of the connexin 40 protein of mouse, rat and human origin. connexin 40 Antibody (B-3) is available as both the non-conjugated anti-connexin 40 antibody form, as well as multiple conjugated forms of anti-connexin 40 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The connexin family of proteins form hexameric complexes called "connexons" that facilitate movement of low molecular weight proteins between cells via gap junctions. Connexin proteins share a common topology of 4 transmembrane alpha-helical domains, two extracellular loops, a cytoplasmic loop, and cytoplasmic N- and C-termini. Many of the key functional differences arise from specific amino-acid substitutions in the most highly conserved domains, the transmembrane and extracellular regions. Each of the approximately 20 connexin isoforms produces channels with distinct permeabilities and electrical and chemical sensitivities; therefore, one connexin usually cannot fully substitute for another. Consequently, a wide variety of malignant phenotypes associate with decreased connexin expression and gap junction communication, dependent on the particular connexin that is effected. For example, upregulation of connexin 40 following cardiac surgery can mark a susceptibility to post-operative atrial fibrillation.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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