CID 755673 (CAS 521937-07-5)
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アプリケーション：
CID 755673 is a selective PKC, PKD, Plk, and HSP 27 inhibitor
CAS 番号:
521937-07-5
Purity:
≥98%
Molecular Weight:
217.22
Molecular Formula:
C12H11NO3
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CID 755673 is a selective and potent protein kinase D1-D3, PKC, CAK, PLK1 and CAMKIIα inhibitor. CID 755673 has been reported to inhibit PKD-mediated protein transport and inhibit proliferation, migration and invasion of prostate cancer cell lines. In SH-SY5Y human neuroblastoma cells, small heat shock protein 27 (HSP27) Ser-82 phosphorylation induced by phorbol-12,13-dibutyrate (PDB) was completely reversed by CID 755673.
参考文献
1. Sharlow, E.R., et al. 2008. J. Biol. Chem. 283: 33516-33526. PMID: 18829454
2. Dokas, L.A., et al. 2011. Neuropharmacology. [Epub ahead of print]. PMID: 21338617
Appearance
:
Powder
Physical State
:
Solid
Solubility
:
Soluble in ethanol (25 mM), and DMSO (100 mM).
保存方法
:
Store at 4° C
Melting Point
:
245-247° C
Boiling Point
:
~531.8° C at 760 mmHg (Predicted)
Density
:
~1.3 g/cm3 (Predicted)
Refractive Index
:
n20D 1.64 (Predicted)
IC50
:
PKD1: IC50 = 0.18 µM; PKD3: IC50 = 0.23 µM; PKD2: IC50 = 0.28 µM; PKC: IC50 >10 µM; CAK: IC50 = 15.3 µM
pK Values
:
pKa: 9 (Predicted)
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
PubChem CID
:
MDL Number
:
MFCD03828155
SMILES
:
C1CC2=C(C(=O)NC1)OC3=C2C=C(C=C3)O
Download SDS (MSDS)
分析表
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