ceruloplasmin Antibody (3B11): sc-69767
- ceruloplasmin Antibody (3B11) is a mouse monoclonal IgG1, cited in 7 publications, provided at 100 µl
- raised against purified ceruloplasmin of human origin
- recommended for detection of ceruloplasmin of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ceruloplasmin Antibody (3B11). This work is in progress.
QUICK LINKS
SEE ALSO...
Ceruloplasmin Antibody (3B11) is a mouse monoclonal IgG1 antibody that detects ceruloplasmin in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Ceruloplasmin is a vital blue plasma glycoprotein synthesized in hepatocytes, playing a crucial role in copper transport throughout the body. Ceruloplasmin, also known as ferroxidase, is composed of three homologous domains resulting from an intragenic triplication, and exists in two splice variants, CP-1 and CP-2, which exhibit differential expression in specific tissues. Ceruloplasmin mRNA is notable in human liver, macrophages, and lymphocytes, highlighting widespread biological significance. Ceruloplasmin binds six or seven cupric ions per molecule and is essential for the peroxidation of Fe(II) transferrin to form Fe(III) transferrin, a critical step in iron metabolism. The structural integrity of ceruloplasmin is crucial for function; while the proteolytically degraded short form retains some ferroxidase activity, only the intact long form can effectively catalyze iron loading into ferritin. Ceruloplasmin induces low-density lipoprotein oxidation in vitro, a process that relies on the presence of a single, chelatable copper atom. A glycosyl phosphatidylinositol (GPI)-anchored variant of ceruloplasmin is expressed by Sertoli cells, suggesting potential significance in reproductive biology. With multifaceted roles in copper and iron metabolism, ceruloplasmin is critical for maintaining homeostasis in the human body, making anti-ceruloplasmin antibody (3B11) an invaluable tool for researchers studying these essential processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ceruloplasmin Antibody (3B11) References:
- Ceruloplasmin in neurodegenerative diseases. | Vassiliev, V., et al. 2005. Brain Res Brain Res Rev. 49: 633-40. PMID: 16269323
- The transfer of iron between ceruloplasmin and transferrins. | White, KN., et al. 2012. Biochim Biophys Acta. 1820: 411-6. PMID: 22040722
- Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease. | Ayton, S., et al. 2013. Ann Neurol. 73: 554-9. PMID: 23424051
- Ceruloplasmin is an endogenous protectant against kainate neurotoxicity. | Shin, EJ., et al. 2015. Free Radic Biol Med. 84: 355-372. PMID: 25843655
- Ceruloplasmin and antioxidative enzymes in pre-eclampsia. | Nikolic, A., et al. 2016. J Matern Fetal Neonatal Med. 29: 2987-93. PMID: 26571141
- Towards mechanized biparametric ceruloplasmin assay. | Strzelak, K., et al. 2020. Talanta. 214: 120881. PMID: 32278433
- Ceruloplasmin Status in Medullary Thyroid Carcinoma. | Razavi, F., et al. 2020. Iran J Public Health. 49: 209-210. PMID: 32309247
- Ceruloplasmin Deamidation in Neurodegeneration: From Loss to Gain of Function. | Zanardi, A. and Alessio, M. 2021. Int J Mol Sci. 22: PMID: 33440850
- Ceruloplasmin as a source of Cu for a fungal pathogen. | Besold, AN., et al. 2021. J Inorg Biochem. 219: 111424. PMID: 33765639
- Molecular Functions of Ceruloplasmin in Metabolic Disease Pathology. | Liu, Z., et al. 2022. Diabetes Metab Syndr Obes. 15: 695-711. PMID: 35264864
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ceruloplasmin Antibody (3B11) | sc-69767 | 100 µl | $322.00 |