Cdc34B Antibody (C-4): sc-376427

Cdc34B Antibody (C-4) is a mouse monoclonal IgG1 antibody that detects Cdc34B in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Cdc34B, also known as UBE2R2 or UBC3B, is a 238 amino acid member of the E2 ubiquitin-conjugating enzyme family, playing a crucial role in the regulation of protein degradation and cell cycle progression. Cdc34B is primarily located in the cytoplasm, where Cdc34B catalyzes the attachment of ubiquitin to target proteins, a process essential for marking them for degradation by the proteasome. Proper functioning of Cdc34B is vital, as Cdc34B ensures the timely removal of regulatory proteins, such as β-catenin, which, when accumulated, can lead to uncontrolled cell proliferation and contribute to oncogenesis. Furthermore, Cdc34B′s activity is modulated by phosphorylation from protein kinase CK2, enhancing Cdc34B′s ability to recognize substrates and regulate β-TrCP, thereby influencing β-catenin degradation. anti-Cdc34B antibody (C-4) is an invaluable tool for researchers studying the intricacies of cell cycle regulation and the underlying mechanisms of various diseases, including cancer.

The preferred Cdc34B antibody is Cdc34B Antibody (E-6): sc-376097.