CD8-β Antibody (53-5.8): sc-18915
- CD8-β Antibody (53-5.8) is a rat monoclonal IgG1 provided at 200 µg/ml
- recommended for detection of CD8-β chain of mouse origin by IP, IF and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CD8-β Antibody (53-5.8). This work is in progress.
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CD8-β Antibody (53-5.8) is a rat monoclonal IgG2a antibody that detects CD8 in mouse samples through immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM) applications. CD8 is a crucial cell surface glycoprotein that forms a heterodimeric complex, typically composed of either two alpha chains or an alpha and a beta chain, and plays a vital role in the immune response by binding to class I major histocompatibility complex (MHC) molecules presented by antigen-presenting cells. This interaction is essential for T cytotoxic cells, which express CD8, as it enhances the recognition of antigens by the T cell receptor (TCR), thereby strengthening the immune response against infected or malignant cells. Additionally, CD8-expressing T cells are implicated in maintaining low levels of HIV expression, highlighting CD8′s importance in both adaptive immunity and viral control. Anti-CD8-β antibody (53-5.8) is an invaluable tool for researchers studying T cell biology, immune responses, and the mechanisms of viral infections, providing insights into the complex interactions that govern immune system function.
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CD8-β Antibody (53-5.8) References:
- Sialic acid capping of CD8beta core 1-O-glycans controls thymocyte-major histocompatibility complex class I interaction. | Moody, AM., et al. 2003. J Biol Chem. 278: 7240-6. PMID: 12459555
- Differential expression of the human CD8beta splice variants and regulation of the M-2 isoform by ubiquitination. | Thakral, D., et al. 2008. J Immunol. 180: 7431-42. PMID: 18490743
- CD8-β ADP-ribosylation affects CD8(+) T-cell function. | Lischke, T., et al. 2013. Eur J Immunol. 43: 1828-38. PMID: 23575529
- Elevated T cell receptor signaling identifies a thymic precursor to the TCRαβ(+)CD4(-)CD8β(-) intraepithelial lymphocyte lineage. | McDonald, BD., et al. 2014. Immunity. 41: 219-29. PMID: 25131532
- CD4+CD8β+ double-positive T cells in skin-draining lymph nodes respond to inflammatory signals from the skin. | Overgaard, NH., et al. 2017. J Leukoc Biol. 102: 837-844. PMID: 28637895
- Genetically Induced Tumors in the Oncopig Model Invoke an Antitumor Immune Response Dominated by Cytotoxic CD8β+ T Cells and Differentiated γδ T Cells Alongside a Regulatory Response Mediated by FOXP3+ T Cells and Immunoregulatory Molecules. | Overgaard, NH., et al. 2018. Front Immunol. 9: 1301. PMID: 29930558
- Combination of CD8β Depletion and Interleukin-15 Superagonist N-803 Induces Virus Reactivation in Simian-Human Immunodeficiency Virus-Infected, Long-Term ART-Treated Rhesus Macaques. | McBrien, JB., et al. 2020. J Virol. 94: PMID: 32669328
- CD45RA, CD8β, and IFNγ Are Potential Immune Biomarkers of Human Cognitive Function. | Esgalhado, AJ., et al. 2020. Front Immunol. 11: 592656. PMID: 33324408
- In vitro IL-15-activated human naïve CD8+ T cells down-modulate the CD8β chain and become CD8αα T cells. | Esgalhado, AJ., et al. 2024. Front Immunol. 15: 1252439. PMID: 38903513
- Specific imaging of CD8 + T-Cell dynamics with a nanobody radiotracer against human CD8β. | De Groof, TWM., et al. 2024. Eur J Nucl Med Mol Imaging. 52: 193-207. PMID: 39218831
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD8-β Antibody (53-5.8) | sc-18915 | 200 µg/ml | $322.00 | |||
CD8-β Antibody (53-5.8) FITC | sc-18915 FITC | 200 µg/ml | $336.00 | |||
CD8-β Antibody (53-5.8) PE | sc-18915 PE | 200 µg/ml | $349.00 |