CD3-ε Antibody (48-2B): sc-1174

CD3-ε Antibody (48-2B) is a hamster monoclonal IgG antibody that detects CD3-ε in mouse and rat samples through applications such as immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). CD3-ε plays a crucial role in the T cell receptor (TCR) complex, which is essential for T cell activation and immune response. Located on the surface of T cells, CD3-ε is one of the five invariant polypeptide chains that form the CD3 complex, which is vital for transmitting signals from the TCR upon antigen recognition. The presence of CD3-ε, along with its associated chains, facilitates the clustering of the TCR and the subsequent activation of intracellular signaling pathways that lead to T cell proliferation and differentiation. Importantly, CD3-ε contains an immunoreceptor tyrosine-based activation motif (ITAM) that is critical for the recruitment of signaling molecules, such as ZAP-70, which further propagate the activation signal. The ability of CD3-ε to interact with other proteins in the signaling cascade underscores its importance in the adaptive immune response, making CD3-ε a valuable target for research in immunology and therapeutic applications. Anti-CD3-ε antibody (48-2B) is an essential tool for studying T cell biology and the mechanisms underlying immune responses.

The preferred CD3-ε antibody is CD3-ε Antibody (UCH-T1): sc-1179.