B7-2 Antibody (B-T7): sc-58915

B7-2 Antibody (B-T7) is a mouse monoclonal IgG1 antibody that detects B7-2 in human samples through western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). B7-2, also known as CD86, plays a crucial role in the immune response by acting as a costimulatory molecule on antigen-presenting cells, where B7-2 binds to CD28 and CTLA-4 receptors on T cells, thereby enhancing T cell activation and proliferation. This interaction is vital for effective T cell activation, which is essential for adaptive immunity. B7-2′s importance extends beyond T cell activation; B7-2 also influences the balance between immune activation and tolerance, making B7-2 a key player in preventing autoimmune responses. B7-2 is predominantly located on the surface of dendritic cells, macrophages, and B cells, which are critical for initiating and regulating immune responses. B7-2 expression on these cells ensures that T cells receive necessary signals for activation in the presence of antigens, thereby facilitating a robust immune response. Anti-B7-2 antibody (B-T7) is an invaluable tool for researchers studying T cell biology and immune regulation mechanisms, providing insights into potential therapeutic targets for immunological diseases.

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B7-2 Antibody (B-T7) References:

1. B7-2 expressed on EL4 lymphoma suppresses antitumor immunity by an interleukin 4-dependent mechanism.  |  Stremmel, C., et al. 1999. J Exp Med. 189: 919-30. PMID: 10075975
2. Differential effects of B7-1 and B7-2 on the costimulation of mouse nonspecific cytotoxic T lymphocyte development in response to anti-CD3 antibody.  |  Makrigiannis, AP., et al. 1999. J Leukoc Biol. 66: 792-802. PMID: 10577511
3. Heterologous expression of human costimulatory molecule B7-2 and construction of B7-2 immobilized polyhydroxyalkanoate nanoparticles for use as an immune activation agent.  |  Li, MC., et al. 2012. BMC Biotechnol. 12: 43. PMID: 22846711
4. Reciprocal expression of co-stimulatory molecules, B7-1 and B7-2, on murine T cells following activation.  |  Prabhu Das, MR., et al. 1995. Eur J Immunol. 25: 207-11. PMID: 7531145
5. B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4.  |  Freeman, GJ., et al. 1995. Immunity. 2: 523-32. PMID: 7538442
6. Differential down-regulation of CD28 by B7-1 and B7-2 engagement.  |  Eck, SC., et al. 1997. Transplantation. 64: 1497-9. PMID: 9392322
7. Upregulation of B7.2, but not B7.1, on B cells from patients with allergic asthma.  |  Hofer, MF., et al. 1998. J Allergy Clin Immunol. 101: 96-102. PMID: 9449507
8. Cryptococcus neoformans differently regulates B7-1 (CD80) and B7-2 (CD86) expression on human monocytes.  |  Vecchiarelli, A., et al. 1998. Eur J Immunol. 28: 114-21. PMID: 9485191
9. Vitamin D differentially regulates B7.1 and B7.2 expression on human peripheral blood monocytes.  |  Clavreul, A., et al. 1998. Immunology. 95: 272-7. PMID: 9824486
10. Enhanced interleukin-2 gene transfer immunotherapy of breast cancer by coexpression of B7-1 and B7-2.  |  Emtage, PC., et al. 1998. J Interferon Cytokine Res. 18: 927-37. PMID: 9858314

The preferred B7-2 antibody is B7-2 Antibody (D-6): sc-28347.