AY 9944 CAS: 366-93-8
MF: C22H28Cl2N2•2HCl
MW: 464.30
A hedgehog inhibitor and DHCR7 inhibitor.

AY 9944 (CAS 366-93-8)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 126ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
AY 9944 is rated 5.0 out of 5 by 1.
5
1
4
0
3
0
2
0
1
0
別名: trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane dihydrochloride
アプリケーション: AY 9944 is a hedgehog inhibitor and DHCR7 inhibitor
CAS 番号: 366-93-8
Purity: ≥99%
Molecular Weight: 464.30
Molecular Formula: C22H28Cl2N22HCl
補足情報: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
* Refer to Certificate of Analysis for lot specific data (including water content).

AY 9944 is an inhibitor of hedgehog (Hh) signaling, possibly via several mechanisms. AY 9944 inhibits DHCR7 (Δ7-dehydrocholesterol reductase) (IC50 = 13 nM), thus reducing cholesterol biosynthesis, and also inhibiting cholesterol esterification. AY 9944 may also directly block the cellular response to hedgehog proteins. AY 9944 is an inhibitor of EBP.


参考文献

1. Yoshida, Y., et al., 1985. Reduction of acid sphingomyelinase activity in human fibroblasts induced by AY-9944 and other cationic amphiphilic drugs. Journal of biochemistry. 98(6): 1669-79. PMID: 2419314
2. Kraml, M., et al., 1964. Inhibition of the conversion of 7-dehydrocholesterol to cholesterol by AY-9944. Biochemical and biophysical research communications. 15(5): 455-7. PMID: 4283982
3. Moebius, F F., et al., 1998. Molecular cloning and expression of the human delta7-sterol reductase. Proceedings of the National Academy of Sciences of the United States of America. 95(4): 1899-902. PMID: 9465114
4. Cooper, M K., et al., 1998. Teratogen-mediated inhibition of target tissue response to Shh signaling. Science (New York, N.Y.). 280(5369): 1603-7. PMID: 9616123
5. Incardona, J P., et al., 1998. The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction. Development (Cambridge, England). 125(18): 3553-62. PMID: 9716521
6. Gofflot, F., et al., 2001. Expression of Sonic Hedgehog downstream genes is modified in rat embryos exposed in utero to a distal inhibitor of cholesterol biosynthesis. Developmental dynamics : an official publication of the American Association of Anatomists. 220(2): 99-111. PMID: 11169843

Physical State :
Solid
Solubility :
Soluble in water (50 mM), and DMSO (14 mg/ml).
保存方法 :
Desiccate at 4° C
Melting Point :
288-293.5° C (lit.)
Refractive Index :
n20D ~1.57 (Predicted)
IC50 :
DHCR7: IC50 = 13 nM
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
RTECS :
GU7025000
PubChem CID :
MDL Number :
MFCD01734586
SMILES :
C1CC(CCC1CNCC2=CC=CC=C2Cl)CNCC3=CC=CC=C3Cl.Cl.Cl

Download SDS (MSDS)

分析表

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

AY 9944 (CAS 366-93-8)  参考文献

他の人がAY 9944 (CAS 366-93-8)をどのように使用したかをご覧ください。 エントリをクリックして、PubMedエントリを表示します。 .

引用 1 to 4 of 4 合計

PMID: # 30212566  Zhou, W.|Debnath, A.|Jennings, G.|Hahn, HJ.|Vanderloop, BH.|Chaudhuri, M.|Nes, WD.|Podust, LM.| et al. 2018. PLoS Pathog. 14: e1007245.

PMID: # 26923021  Kim, Y. et al. 2016. J. Alzheimers Dis. 51: 1057-68.

PMID: # 32994291  mSystems.

PMID: # 25985440  Virology. 218-28.

引用 1 to 4 of 4 合計
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 137ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 7ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

サンタクルーズバイオテクノロジーは生物医学研究市場向けの製品の開発における世界的リーダです。 下記フリー ダイヤルにお電話ください: 1-800-457-3801。Copyright © 2007-2021 Santa Cruz Biotechnology, Inc.全著作権所有。"Santa Cruz Biotechnology"、 及びSanta Cruz Biotechnology, Inc. ロゴ、 "Santa Cruz Animal Health"、 "San Juan Ranch"、 "Supplement of Champions"、 San Juan Ranch ロゴ、 "Ultracruz"、 "Chemcruz"、 "Immunocruz"、 "Exactacruz"、 と "EZ Touch"はサンタクルーズバイオテクノロジーの登録商標です。 商標はそれぞれの所有者に帰属します。