Arctigenin CAS: 7770-78-7
MF: C21H24O6
MW: 372.41
A dibenzyl butyrolactone lignan with antiinflammatory and antioxidant properties.

Arctigenin (CAS 7770-78-7)

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別名: (-)-Arctigenin
アプリケーション: Arctigenin is a dibenzyl butyrolactone lignan with antiinflammatory and antioxidant properties
CAS 番号: 7770-78-7
Purity: ≥97%
Molecular Weight: 372.41
Molecular Formula: C21H24O6
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* Refer to Certificate of Analysis for lot specific data (including water content).
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Arctigenin is a dibenzyl butyrolactone lignan agent with antiinflammatory and antioxidant properties. Studies describe arctigenin to potently block TNF- α production and NO secretion. MAP kinase studies show that arctigenin effectively inhibits the activity of MAP kinases and AP-1 activation through vigorous inhibition of MKK. Additional studies report that arctigenin acts as a potent inhibitor of PAC-1 activity. Arctigenin has also been shown to bind to kainic acid receptors and protect neurons from neurodegeneration induced by glutamate and inhibit HIV-1 integrase. Furthermore, this compound acts as an inhibitor of IκB phosphorylation. Arctigenin is an inhibitor of MEK-1 and Topo II.


参考文献

1. Eich, E., et al. 1996. J. Med. Chem. 39: 86-95. PMID: 8568830
2. Cho, J.Y., et al. 1999. J. Pharm. Pharmacol. 51: 1267-1273. PMID: 10632084
3. Jang, Y.P., et al. 2002. J. Neurosci. Res. 68: 233-240. PMID: 11948668
4. Cho, M.K., et al. 2004. Int. Immunopharmacol. 4: 1419-1429. PMID: 15313439
5. Awale, S., et al. 2006. Cancer Res. 66: 1751-1757. PMID: 16452235

Physical State :
Solid
Derived From :
Arctium lappa
Solubility :
Soluble in DMSO (34 mg/ml), water (sparingly), and ethanol (25 mM).
保存方法 :
Store at -20° C
Melting Point :
219.94° C (Predicted)
Boiling Point :
567.00° C at 760 mmHg (Predicted)
Density :
1.23 g/cm3 (Predicted)
Refractive Index :
n20D 1.58 (Predicted)
IC50 :
MKK1: IC50 = 0.5 nM; Dual specificity MEK Kinase-1: IC50 = 1 nM (human); LPS-induced iNOS expression: IC50 = 10 nM; Herpesvirus 5: IC50 = 2.1 µM (human)
pK Values :
pKa: 10.03 (Predicted)
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD00870597
SMILES :
COC1=C(C=C(C=C1)C[[email protected]]2COC(=O)[[email protected]@H]2CC3=CC(=C(C=C3)O)OC)OC

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Arctigenin (CAS 7770-78-7)  参考文献

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引用 1 to 10 of 13 合計

PMID: # 32405377  Kim, JE.|Lee, NH.|Kim, YH.|Kim, YE.|Lim, TG.|Song, KM.| et al. 2020. Food Sci Nutr. 8: 2205-2213.

PMID: # 30909158  Wang, X.|Gao, M.|Zhang, J.|Ma, Y.|Qu, W.|Liang, J.|Wu, H.|Wen, H.| et al. 2019. Redox Biol. 24: 101153.

PMID: # 29436614  Maxwell, T. et al. 2018. Int. J. Oncol. 52: 1339-1349.

PMID: # 29715756  Han, F. et al. 2018. Biomed. Pharmacother. 103: 1127-1136.

PMID: # 28035371  Maxwell, T. et al. 2017. Int. J. Oncol. 50: 727-735.

PMID: # 26550018  Shin, HS. et al. 2015. Evidence-based complementary and alternative medicine : eCAM. 2015: 368105.

PMID: # 24842412  Huang, K. et al. 2014. Basic & clinical pharmacology & toxicology. 115: 507-11.

PMID: # 24395429  Wang, HQ. et al. 2014. Journal of biochemical and molecular toxicology. 28: 39-45.

PMID: # 23744558  Gu, Y. et al. 2013. Anti-cancer drugs. 24: 781-91.

PMID: # 22770942  Yao, X. et al. 2012. International immunopharmacology. 14: 138-44.

引用 1 to 10 of 13 合計
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