Ambroxol hydrochloride CAS: 23828-92-4
MF: C13H18Br2N2O•HCl
MW: 414.6
An expectorant antioxidant and antiinflammatory agent.

Ambroxol hydrochloride (CAS 23828-92-4)

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アプリケーション: An expectorant antioxidant and antiinflammatory agent
CAS 番号: 23828-92-4
Purity: 98%
Molecular Weight: 414.6
Molecular Formula: C13H18Br2N2O•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ambroxol hydrochloride is a small molecule expectorant and mucolytic agent with antioxidant and antiinflammatory effects. Ambroxol stimulates the secretion of surfactant which decreases mucus adhesion to the bronchial lining and produces expectorant effects. The antioxidant effects of Ambroxol are well demonstrated, where lipid peroxidation initiated by t-butyl hydroperoxide or doxorubicin is suppressed in the presence Ambroxol, and scavenging of hydroxyl radicals and cellular superoxide radical anions is also observed. Ambroxol produces antiinflammatory effects by blocking the expression of proinflammatory messengers, inhibiting the release of histamine from mast cells and the generation of cytokines and interleukins. Ambroxol hydrochloride is an inhibitor of Sodium Channel Protein.


参考文献

1. Disse, B.G. 1987. Eur J Respir Dis Suppl. 153: 255-262. PMID: 3322865
2. Wilke, A., et al. 1987. Respiration. 52: 129-136. PMID: 3671891
3. Nowak, D., et al. 1995. Free Radic. Biol. Med. 19: 659-663. PMID: 8529925
4. Gibbs, B.F., et al. 1999. Inflamm. Res. 48: 86-93. PMID: 10202994
5. Stetinová, V., et al. 2004. Clin. Exp. Med. 4: 152-158. PMID: 15599665
6. Laurent, A., et al. 2004. Hepatology. 39: 1277-1285. PMID: 15122756
7. Su, X., et al. 2004. Intensive Care Med. 30: 133-140. PMID: 14504727
8. Beeh, K.M., et al. 2008. Eur. J. Med. Res. 13: 557-562. PMID: 19073395
9. Malerba, M., 2008. Expert Opin Drug Metab Toxicol. 4: 1119-1129. PMID: 18680446

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in methanol, water (~5 mg/ml), ethanol (~5 mg/ml), and DMSO (50 mM). Insoluble in ether.
保存方法 :
Store at 4° C
Melting Point :
>235° C (dec.)
IC50 :
tetrodotoxin (TTX)-resistant channels: IC50 = 35.2 µM; TTX-sensitive subtypes: IC50 = 111.5 µM
pK Values :
pKb: 8.69
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
RTECS :
GV8423000
PubChem CID :
108013
Merck Index :
14: 386
MDL Number :
MFCD00078932
EC Number :
242-500-3
SMILES :
C1CC(CCC1NCC2=CC(=CC(=C2N)Br)Br)O.Cl

Download SDS (MSDS)

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