Aluminum chloride hexahydrate CAS: 7784-13-6
MF: AlCl3•6H2O
MW: 241.43
An aqueous AlCl3 for that has varied effects on BACE, BACE2, SOD-2, GABA and Taurine.

Aluminum chloride hexahydrate (CAS 7784-13-6)

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アプリケーション: Aluminum chloride hexahydrate is an aqueous AlCl3 for that has varied effects on BACE, BACE2, SOD-2, GABA and Taurine
CAS 番号: 7784-13-6
Purity: ≥99%
Molecular Weight: 241.43
Molecular Formula: AlCl36H2O
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* Refer to Certificate of Analysis for lot specific data (including water content).
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Aluminum chloride hexahydrate is the aqueous form of aluminum chloride. The solution is acidic and has a good conductance for electricity. In neuronal SH-SY5Y cells exposed to aluminum chloride, the cells displayed early mRNA expression upregulation of BACE (β site APP-cleaving enzyme 1) and BACE2. Aluminimum chloride has displayed activation and upregulation of SOD-2 (MnSOD, manganese superoxide dismutase), a toxic superoxide radical scavenger enzyme, in Schizosaccharomyces pombe. In rat cortical astrocytes, Aluminum chloride has been documented to stimulate the release of both TAUT (Taurine) and GABA. Aluminum chloride has been observed to inhibit the calcium-dependent and -independent protease degradation of neurofilament proteins in mouse CNS cytoskeletal preparations.


参考文献

1. Albrecht, J., et al. 1991. Neurochem. Int. 18: 125-129. PMID: 20504685
2. Shea, T.B., et al. 1992. FEBS Lett. 307: 195-198. PMID: 1644172
3. Jung, H.I., et al. 2002. Mol. Cells. 14: 300-304. PMID: 12442905
4. Castorina, A., et al. 2010. Cell Biol. Toxicol. 26: 367-377. PMID: 20111991

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (477 mg/ml at 20° C), alcohol, ether, glycerol, propylene glycol, benzophenone, benzene, nitrobenzene, carbon tetrachloride, and chloroform.
保存方法 :
Store at room temperature
Melting Point :
100° C
Density :
2.4 g/cm3 at 20° C
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
RTECS :
BD0530000
PubChem CID :
24564
Merck Index :
14: 337
MDL Number :
MFCD00149134
EC Number :
231-208-1
SMILES :
O.O.O.O.O.O.[Al](Cl)(Cl)Cl

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