Wnt Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $96.00 $292.00 | 27 | |
IWP-2 is a selective inhibitor of the Wnt signaling pathway, known for its unique ability to disrupt the interaction between Wnt ligands and their Frizzled receptors. This compound stabilizes the β-catenin destruction complex, leading to decreased β-catenin levels in the nucleus. Its distinct molecular interactions modulate the pathway's dynamics, influencing cellular fate decisions and developmental processes. The compound exhibits a rapid kinetic profile, underscoring its role in regulating cellular signaling. | ||||||
β-Catenin/Tcf Inhibitor, FH535 | 108409-83-2 | sc-221398 sc-221398A | 10 mg 50 mg | $182.00 $374.00 | 7 | |
FH535 is a potent inhibitor of the β-catenin/Tcf transcriptional complex, specifically targeting the Wnt signaling pathway. It disrupts the binding of β-catenin to Tcf/Lef transcription factors, effectively modulating gene expression. This compound showcases unique interaction dynamics that alter cellular signaling cascades, influencing processes such as cell proliferation and differentiation. Its distinct kinetic properties allow for precise regulation of pathway activity, making it a critical tool in studying Wnt-related mechanisms. | ||||||
IWR-1-endo | 1127442-82-3 | sc-295215 sc-295215A | 5 mg 10 mg | $82.00 $135.00 | 19 | |
IWR-1-endo is a selective modulator of the Wnt signaling pathway, functioning primarily as an inhibitor of the porcupine enzyme, which is crucial for the palmitoylation of Wnt proteins. By preventing this modification, IWR-1-endo effectively reduces the secretion of Wnt ligands, thereby diminishing their interaction with Frizzled receptors. This compound exhibits unique binding affinities that influence downstream signaling events, impacting cellular fate decisions and tissue homeostasis. | ||||||
IWR-1-exo | 1127442-87-8 | sc-295216 sc-295216A | 5 mg 10 mg | $77.00 $121.00 | 2 | |
IWR-1-exo is a potent modulator of the Wnt signaling pathway, acting as a selective inhibitor of the porcupine enzyme. It disrupts the palmitoylation process of Wnt proteins, leading to altered ligand availability. This compound exhibits distinct kinetic properties, influencing the rate of Wnt ligand secretion and subsequent receptor engagement. Its unique molecular interactions can significantly affect downstream signaling cascades, thereby impacting cellular behavior and developmental processes. | ||||||
Demethoxy Curcumin | 22608-11-3 | sc-391590 | 10 mg | $268.00 | ||
Demethoxy Curcumin is a notable compound that influences the Wnt signaling pathway through its ability to modulate β-catenin activity. By interacting with specific protein complexes, it alters the stability and localization of β-catenin, thereby affecting gene expression. Its unique structural features allow for selective binding, which can modify the dynamics of cellular signaling networks. This compound's distinct reactivity and interaction profiles contribute to its role in regulating cellular processes. | ||||||
CCT036477 | 305372-78-5 | sc-391631A sc-391631 | 5 mg 25 mg | $109.00 $437.00 | 1 | |
CCT036477 is a selective inhibitor of the Wnt signaling pathway, characterized by its ability to disrupt the interaction between β-catenin and TCF/LEF transcription factors. This compound exhibits unique binding affinity, leading to altered transcriptional activity. Its distinct molecular interactions can modulate downstream signaling cascades, influencing cellular fate decisions. The compound's kinetic properties facilitate rapid engagement with target proteins, enhancing its regulatory potential in cellular environments. | ||||||
KY02111 | 1118807-13-8 | sc-397043 sc-397043A | 5 mg 25 mg | $79.00 $336.00 | ||
KY02111 is a potent modulator of the Wnt signaling pathway, distinguished by its capacity to interfere with the stabilization of β-catenin. This compound engages in specific molecular interactions that prevent β-catenin from translocating to the nucleus, thereby inhibiting its transcriptional activity. Its unique reaction kinetics allow for a swift onset of action, effectively altering cellular signaling dynamics and influencing developmental processes at the molecular level. | ||||||
PNU-74654 | 113906-27-7 | sc-258020 sc-258020A | 5 mg 25 mg | $131.00 $495.00 | 7 | |
PNU-74654 is a selective Wnt pathway modulator that uniquely disrupts the interaction between Wnt ligands and their receptors, leading to a decrease in downstream signaling. This compound exhibits distinct binding affinities, which facilitate its role in altering the conformation of key proteins involved in the pathway. Its rapid kinetics enable immediate effects on cellular processes, making it a significant player in the regulation of cellular fate and differentiation. | ||||||