KLH is a large, multi-subunit, oxygen-carrying protein found in the hemolymph of the marine gastropod, the Keyhole Limpet (genus Megathura).Hemocyanins, including KLH, are copper-containing proteins that bind and transport oxygen in many mollusks and arthropods. They're notable for their blue color when oxygenated. KLH, in particular, is of significant interest to biomedical research and development due to its strong immunogenic properties.KLH is composed of two distinct subunits known as KLH1 and KLH2, which are assembled into large, cylindrical structures. Each subunit is built from multiple copies of a ~350 kDa protein, which associate to form the decameric subunits. These can then aggregate into didecamers or multidecamers to form the functional hemocyanin.
The KLH protein is often used as a carrier protein in vaccine development because it can stimulate the immune system and enhance the body's response to an associated antigen. However, the specific structure and immunogenic properties can vary between KLH1 and KLH2.If "Keyhole Limpet Hemocyanin A" refers to a specific subunit or variant of KLH, I recommend checking the latest research or reaching out to experts in the field for more information. It's also important to note that ethical considerations should be taken into account when using KLH, as the Keyhole Limpet is a non-domesticated species collected from the wild.
| 製品名 | CAS # | カタログ # | 数量 | 価格 | 引用文献 | レーティング |
|---|---|---|---|---|---|---|
Polyinosinic acid - polycytidylic acid sodium salt, double-stranded | 42424-50-0 | sc-204854 sc-204854A | 10 mg 100 mg | $139.00 $650.00 | 2 | |
二本鎖RNAの合成アナログで、KLHを含むワクチン製剤の免疫賦活剤として使用される。 | ||||||
Squalene | 111-02-4 | sc-281155 sc-281155A sc-281155B | 10 ml 100 ml 500 ml | $48.00 $90.00 $211.00 | 1 | |
ワクチン中のKLHに対する免疫反応を増強するために、一部のアジュバント製剤に使用される有機化合物。 | ||||||
Chitosan | 9012-76-4 | sc-221421 sc-221421A sc-221421B sc-221421D sc-221421C | 10 g 25 g 100 g 8 kg 500 g | $40.00 $54.00 $132.00 $3274.00 $292.00 | 6 | |
ワクチン製剤のデリバリーシステムとして使用され、KLHに対する免疫反応を高める可能性がある。 | ||||||
Imiquimod | 99011-02-6 | sc-200385 sc-200385A | 100 mg 500 mg | $66.00 $278.00 | 6 | |
Toll様受容体作動薬は、KLHベースのワクチン製剤において免疫系を刺激するために使用できる。 | ||||||
GM-CSF | 83869-56-1 | sc-280759 | 5 µg | $516.00 | 1 | |
ワクチンにおいてKLHに対する免疫反応を増強するアジュバントとして使用されることもある。 | ||||||