F-Spondin inhibitors are a specialized class of compounds that target and inhibit the activity of F-Spondin, a protein that plays a critical role in the development and maintenance of the nervous system. F-Spondin, also known as Spondin-1, is an extracellular matrix protein predominantly expressed in the embryonic floor plate, a structure crucial for the proper guidance of axons during neural development. By modulating the interactions between F-Spondin and its associated receptors or binding partners, F-Spondin inhibitors provide researchers with the ability to study the intricate processes involved in neural patterning, axon guidance, and synaptic formation.
These inhibitors are particularly valuable in research focused on understanding the complex signaling pathways that F-Spondin is involved in, such as those related to neuron outgrowth, cell adhesion, and the organization of the extracellular matrix. By inhibiting F-Spondin, scientists can dissect its role in these processes and gain insights into how it influences the structural and functional aspects of the nervous system. Additionally, F-Spondin inhibitors enable the exploration of how disruptions in F-Spondin activity might contribute to neurodevelopmental disorders or other conditions characterized by abnormal neural connectivity. This makes them indispensable tools for advancing our knowledge of neurobiology, particularly in areas related to the molecular mechanisms governing neural development and the establishment of neural circuits. Through the use of F-Spondin inhibitors, researchers can further elucidate the roles of extracellular matrix proteins in the central nervous system, enhancing our overall understanding of neural architecture and its regulation.
製品名 | CAS # | カタログ # | 数量 | 価格 | 引用文献 | レーティング |
---|---|---|---|---|---|---|
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $35.00 $115.00 $515.00 | 26 | |
タンキナーゼ阻害剤で、Axinを安定化し、Wntシグナル伝達を阻害する。Wnt経路におけるβ-カテニンの制御を研究し、潜在的にスプジンの機能を阻害する研究に使用される。 | ||||||
Tirofiban, Hydrochloride | 150915-40-5 | sc-208440 | 10 mg | $211.00 | ||
フィブリノーゲン受容体(インテグリンαIIbβ3)の非ペプチド阻害剤。抗血小板薬として臨床的に使用され、血栓症のリスクを低減し、潜在的にスポンジン機能を阻害する。 | ||||||
Y-27632 dihydrochloride | 129830-38-2 | sc-216067 sc-216067A | 1 mg 5 mg | $170.00 $430.00 | 5 | |
広く使用されているROCKの選択的阻害剤。細胞生物学の研究、特に細胞運動とアポトーシスの分野で役立っており、潜在的にスドニン機能を阻害する可能性がある。 | ||||||
Cilengitide | 188968-51-6 | sc-507335 | 5 mg | $215.00 | ||
インテグリンαvβ3およびαvβ5を阻害する合成ペプチド。主に癌治療における血管新生阻害特性について研究されており、潜在的にスポンジン機能を阻害する可能性がある。 | ||||||
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $94.00 $286.00 | 27 | |
Wntの産生を阻害し、それによりWntシグナル伝達を阻害する。IWP-2は、Wntの処理と分泌に関与する膜結合型O-アシル転移酵素であるポルキュパイン(PORCN)を選択的に阻害し、潜在的にスポンジン機能を阻害する。 | ||||||
LGK 974 | 1243244-14-5 | sc-489380 sc-489380A | 5 mg 50 mg | $352.00 $1270.00 | 2 | |
特に、Wntシグナル伝達に依存して成長および生存する腫瘍の研究に用いられ、潜在的にスポンジン機能を阻害する。 |