Date published: 2025-11-27

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DGCR6L阻害剤

DDX26B Inhibitors constitute a specific class of chemical compounds designed to selectively impede the activity of the DDX26B enzyme. DDX26B, also known as DEAD-box helicase 26B, belongs to the broader family of DEAD-box helicases, which are involved in RNA metabolism and contribute to various aspects of RNA processing, including transcription, splicing, and translation. The development of inhibitors targeting DDX26B is pivotal for scientific exploration, offering specialized tools to elucidate the molecular functions and regulatory roles associated with this particular helicase. As a member of the DEAD-box helicase family, DDX26B likely plays a role in unwinding RNA secondary structures, facilitating RNA-protein interactions, and modulating the dynamic landscape of cellular RNA processing events.

The synthesis and optimization of DDX26B inhibitors necessitate a thorough understanding of the enzyme's structural features and its interactions within cellular pathways. These inhibitors are meticulously designed for specificity, aiming to selectively bind to key regions of DDX26B and interfere with its normal helicase activities. By utilizing DDX26B inhibitors in experimental settings, researchers can investigate the consequences of enzyme inhibition on RNA processing dynamics, shedding light on the specific substrates and molecular pathways governed by DDX26B. The study of DDX26B inhibitors contributes to the broader comprehension of cellular RNA metabolism, providing insights into the intricate molecular mechanisms that regulate gene expression and RNA-related processes in cells.

関連項目

製品名CAS #カタログ #数量価格引用文献レーティング

α-Amanitin

23109-05-9sc-202440
sc-202440A
1 mg
5 mg
$260.00
$1029.00
26
(2)

α-アマニチンはRNAポリメラーゼIIを阻害し、転写を阻害してDGCR6L mRNAの合成を妨げる。

Puromycin dihydrochloride

58-58-2sc-108071
sc-108071B
sc-108071C
sc-108071A
25 mg
250 mg
1 g
50 mg
$40.00
$210.00
$816.00
$65.00
394
(15)

ピューロマイシンはタンパク質合成の早期終結を誘導し、翻訳に影響を与え、DGCR6Lレベルを低下させる。

Actinomycin D

50-76-0sc-200906
sc-200906A
sc-200906B
sc-200906C
sc-200906D
5 mg
25 mg
100 mg
1 g
10 g
$73.00
$238.00
$717.00
$2522.00
$21420.00
53
(3)

アクチノマイシンC1はDNAに結合して転写を阻害し、DGCR6Lの発現を減少させる。

Cordycepin

73-03-0sc-203902
10 mg
$99.00
5
(1)

コルディセピンはmRNAの合成を阻害し、転写に影響を与え、DGCR6Lのダウンレギュレーションに寄与する。

Flavopiridol Hydrochloride

131740-09-5sc-207687
10 mg
$311.00
(2)

フラボピリドールはサイクリン依存性キナーゼ阻害剤で、RNAポリメラーゼIIのリン酸化を防ぎ、DGCR6Lの転写を阻害する。

Ellipticine

519-23-3sc-200878
sc-200878A
10 mg
50 mg
$142.00
$558.00
4
(1)

エリプチシンはDNAにインターカレートして転写を阻害し、DGCR6Lの発現を減少させる。

Streptonigrin

3930-19-6sc-500892
sc-500892A
1 mg
5 mg
$102.00
$357.00
1
(1)

Streptolydiginは細菌のRNAポリメラーゼを阻害し、転写を阻害することによって間接的にDGCR6Lの発現に影響を与える。

Mycophenolic acid

24280-93-1sc-200110
sc-200110A
100 mg
500 mg
$68.00
$261.00
8
(1)

ミコフェノール酸はイノシン一リン酸デヒドロゲナーゼを阻害し、プリン合成を阻害することにより間接的にDGCR6Lの発現に影響を与える。

Blasticidin S Hydrochloride

3513-03-9sc-204655A
sc-204655
25 mg
100 mg
$360.00
$475.00
20
(2)

Blasticidin Sは翻訳中の早期終結を誘導し、タンパク質合成を阻害し、DGCR6Lレベルを低下させる。