TRB-2 Antibody (B-06): sc-100878
- TRB-2 Antibody (B-06) is a mouse monoclonal IgG2b λ, cited in 6 publications, provided at 100 µg/ml
- raised against recombinant TRB-2 of human origin
- recommended for detection of TRB-2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TRB-2 Antibody (B-06). This work is in progress.
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TRB-2 Antibody (B-06) is a mouse monoclonal IgG2b antibody that detects TRB-2 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). TRB-2, also known as Tribbles homolog 2, is a cytoplasmic pro-apoptotic protein that plays a crucial role in regulating apoptosis and cellular signaling pathways. TRB-2 is particularly important due to involvement in the MAP kinase pathway, where TRB-2 modulates the activity of mitogen-activated protein kinases (MAPKs) in response to cellular stress and growth signals. The ability of TRB-2 to interact with and stabilize MAPKKs highlights TRB-2′s significance in maintaining cellular homeostasis and influencing cell fate decisions. TRB-2 is predominantly expressed in peripheral blood leukocytes, which underscores TRB-2′s potential role in immune responses and hematopoiesis. The unique structure of TRB-2, characterized by a protein kinase-like domain that lacks active site lysine, suggests TRB-2 may function as a regulatory protein rather than a traditional kinase, further emphasizing TRB-2′s importance in cellular signaling networks. With versatile applications and critical biological functions, anti-TRB-2 antibody (B-06) is an essential tool for researchers studying apoptosis and MAPK signaling pathways.
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TRB-2 Antibody (B-06) References:
- Identification of tribbles homolog 2 as an autoantigen in autoimmune uveitis by phage display. | Zhang, Y., et al. 2005. Mol Immunol. 42: 1275-81. PMID: 15950723
- Trb2, a mouse homolog of tribbles, is dispensable for kidney and mouse development. | Takasato, M., et al. 2008. Biochem Biophys Res Commun. 373: 648-52. PMID: 18593568
- Elevated Tribbles homolog 2-specific antibody levels in narcolepsy patients. | Cvetkovic-Lopes, V., et al. 2010. J Clin Invest. 120: 713-9. PMID: 20160349
- Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding. | Keeshan, K., et al. 2010. Blood. 116: 4948-57. PMID: 20805362
- The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner. | Bailey, FP., et al. 2015. Biochem J. 467: 47-62. PMID: 25583260
- Murine tribbles homolog 2 deficiency affects erythroid progenitor development and confers macrocytic anemia on mice. | Lin, KR., et al. 2016. Sci Rep. 6: 31444. PMID: 27550848
- Tribbles homolog 2 promotes hepatic fibrosis and hepatocarcinogenesis through phosphatase 1A-Mediated stabilization of yes-associated protein. | Xiang, D., et al. 2021. Liver Int. 41: 1131-1147. PMID: 33386706
- Tribbles homolog 2 (Trib2), a pseudo serine/threonine kinase in tumorigenesis and stem cell fate decisions. | Fang, Y., et al. 2021. Cell Commun Signal. 19: 41. PMID: 33794905
- The role of tribbles homolog 2 in vascular smooth muscle cell proliferation. | Takaguri, A., et al. 2023. Cell Biol Int. 47: 787-795. PMID: 36626273
- The role of tribbles homolog 2 in cell proliferation. | Zhang, W., et al. 2025. Cell Commun Signal. 23: 5. PMID: 39762856
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TRB-2 Antibody (B-06) | sc-100878 | 100 µg/ml | $339.00 |