Molecular structure of SU 16f, CAS Number: 251356-45-3
SU 16f (CAS 251356-45-3)
Application:
SU 16f is a potent PDGFRβ inhibitor
CAS Number:
251356-45-3
Purity:
>98%
Molecular Weight:
386.44
Molecular Formula:
C24H22N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SU 16f is a selective PDGFRbeta inhibitor with an IC50=10nM. In vitro studies demonstrate that SU 16f also inhibits HUVEC and NIH3T3 cell proliferation with an IC50=0.11muM. In addition, SU 16f displays 14 fold selectivity towards PDGFRbeta compared to Flk-1 (VEGFR2), 229-fold over Flg (FGFR1) and 10000-fold over EGFR. SU 16f is an inhibitor of Flk-1.
SU 16f (CAS 251356-45-3) References
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- Akt- and Erk-mediated regulation of proliferation and differentiation during PDGFRβ-induced MSC self-renewal. | Gharibi, B., et al. 2012. J Cell Mol Med. 16: 2789-801. PMID: 22805337
- Association between in vivo bone formation and ex vivo migratory capacity of human bone marrow stromal cells. | Andersen, RK., et al. 2015. Stem Cell Res Ther. 6: 196. PMID: 26450135
- A PPARγ transcriptional cascade directs adipose progenitor cell-niche interaction and niche expansion. | Jiang, Y., et al. 2017. Nat Commun. 8: 15926. PMID: 28649987
- PDGF Modulates BMP2-Induced Osteogenesis in Periosteal Progenitor Cells. | Wang, X., et al. 2019. JBMR Plus. 3: e10127. PMID: 31131345
- Paracrine Crosstalk between Fibroblasts and ER+ Breast Cancer Cells Creates an IL1β-Enriched Niche that Promotes Tumor Growth. | Chatterjee, S., et al. 2019. iScience. 19: 388-401. PMID: 31419632
- A PDGFRβ-PI3K signaling axis mediates periosteal cell activation during fracture healing. | Doherty, L., et al. 2019. PLoS One. 14: e0223846. PMID: 31665177
- Pericyte-Mediated Tissue Repair through PDGFRβ Promotes Peri-Infarct Astrogliosis, Oligodendrogenesis, and Functional Recovery after Acute Ischemic Stroke. | Shibahara, T., et al. 2020. eNeuro. 7: PMID: 32046974
- Identification of SARS-CoV-2 3CL Protease Inhibitors by a Quantitative High-Throughput Screening. | Zhu, W., et al. 2020. ACS Pharmacol Transl Sci. 3: 1008-1016. PMID: 33062953
- YAP1/TEAD1 upregulate platelet-derived growth factor receptor beta to promote vascular smooth muscle cell proliferation and neointima formation. | Osman, I., et al. 2021. J Mol Cell Cardiol. 156: 20-32. PMID: 33753119
- M2 Macrophages Promote PDGFRβ+ Pericytes Migration After Spinal Cord Injury in Mice via PDGFB/PDGFRβ Pathway. | Li, Z., et al. 2021. Front Pharmacol. 12: 670813. PMID: 33935795
- SU16f inhibits fibrotic scar formation and facilitates axon regeneration and locomotor function recovery after spinal cord injury by blocking the PDGFRβ pathway. | Li, Z., et al. 2022. J Neuroinflammation. 19: 95. PMID: 35429978
- Imatinib inhibits pericyte-fibroblast transition and inflammation and promotes axon regeneration by blocking the PDGF-BB/PDGFRβ pathway in spinal cord injury. | Yao, F., et al. 2022. Inflamm Regen. 42: 44. PMID: 36163271
- PDGF inhibits BMP2-induced bone healing. | Novak, S., et al. 2023. NPJ Regen Med. 8: 3. PMID: 36631491
- Age-dependent Pdgfrβ signaling drives adipocyte progenitor dysfunction to alter the beige adipogenic niche in male mice. | Benvie, AM., et al. 2023. Nat Commun. 14: 1806. PMID: 37002214
Inhibitor of:
Flk-1, PDGFR-beta, and Tyrosine Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SU 16f, 10 mg | sc-204307 | 10 mg | $214.00 | |||
SU 16f, 50 mg | sc-204307A | 50 mg | $880.00 |