SPARC Antibody (AON-1): sc-33645

SPARC Antibody (AON-1) is a mouse monoclonal IgG3 kappa antibody that detects SPARC in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-SPARC antibody (AON-1) is available in a non-conjugated form, allowing for versatile experimental use. SPARC, or secreted protein acidic and rich in cysteine, plays a crucial role in various biological processes, including tissue remodeling and wound healing. SPARC is primarily secreted by endothelial cells and is notably abundant in the parietal endoderm of mouse embryos and the human placenta. SPARC′s structure, characterized by a high content of acidic and glycine-rich domains, is essential for regulating cell adhesion and migration. SPARC interacts with several extracellular matrix proteins, including collagen and fibronectin, which are vital for maintaining tissue integrity and facilitating cellular communication. SPARC′s ability to modulate the behavior of endothelial cells, particularly in response to injury, underscores its importance in vascular biology and potential implications in pathological conditions such as cancer and fibrosis.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SPARC Antibody (AON-1) has 8 citations in a variety of scientific publications.

Primary antibodies like Anti-SPARC Antibody (AON-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SPARC Antibody (AON-1) Specifications

Alternate Product Name: SPARC

Product Clone Name: AON-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids:

Epitope Target: SPARC

Epitope Species: bovine

Product Reactivity/Detection: SPARC

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: bovine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for SPARC Antibody (AON-1): N/A

The preferred SPARC antibody is SPARC Antibody (AON-5031): sc-73472.