SGI-1027 (CAS 1020149-73-8)
Nomi alternativi:
N-[4-[(2-Amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide
Applicazione:
SGI-1027 is an inhibitor of the DNA methyltransferases
Numero CAS:
1020149-73-8
Peso molecolare:
461.52
Formula molecolare:
C27H23N7O
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
SGI-1027 is an inhibitor of the DNA methyltransferases DNMT1, DNMT3A, and DNMT3B. It has been shown to cause the degradation of DNMT1 and to reactivate silenced tumor suppressor genes by reducing CpG island hypermethylation
Stato fisico
:
Solid
Solubilità
:
Soluble in DMSO (92 mg/ml at 25 °C), DMF (~5 mg/ml), DMSO:PBS (pH 7.2)(1:4) (~0.2 mg/ml), water (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C).
CONSERVAZIONE
:
Store at -20° C
Densità
:
~1.4 g/cm3 (Predicted)
Indice di rifrazione
:
n20D 1.79 (Predicted)
IC50
:
Dnmt1: IC50 = 0.85 µM (human); Cytotoxicity against human U937 cells: IC50 = 1.7 µM; Dnmt3b: IC50 = 7.5 µM (murine); Dnmt3a: IC50 = 8 µM (murine); CpG DNA methylase M.SssI: IC50 = 13.5 µM (mycoplasma Spiroplasma sp. strain MQ1)
Valori pK
:
pKa: 9.82 (Predicted), pKb: 0.18 (Predicted)
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
PubChem CID
:
SMILES
:
CC1=CC(=NC(=N1)N)NC2=CC=C(C=C2)NC(=O)C3=CC=C(C=C3)NC4=CC=NC5=CC=CC=C54
Download SDS (MSDS)
CERTIFICATO DI ANALISI
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