Molecular structure of Salermide, CAS Number: 1105698-15-4
Salermide (CAS 1105698-15-4)
See product citations (3)
Alternate Names:
N-[3-[[(2-hydroxy-1-naphthalenyl)methylene]amino]phenyl]-a-methyl-benzeneacetamide
Application:
Salermide is an inhibitor of SIRT1, SIRT2, and HDAC
CAS Number:
1105698-15-4
Purity:
≥98%
Molecular Weight:
394.47
Molecular Formula:
C26H22N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Salermide is a reverse amide with strong inhibitory effects on SIRT1 (Sirtuin 1) and SIRT2 (Sirtuin 2). SIRT1/2 both belong to the family of NAD+-dependent class III histone deacetylases and are shown to target protein 53, a cell cycle regulator. Salermide is shown to induce acetylation of p53 and cause cell apoptosis. Salermide also inhibits members of HDAC3 (class III HDACs).
Salermide (CAS 1105698-15-4) References
- Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect. | Lara, E., et al. 2009. Oncogene. 28: 781-91. PMID: 19060927
- SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2. | Peck, B., et al. 2010. Mol Cancer Ther. 9: 844-55. PMID: 20371709
- SIRT1 and Connexin40 Mediate the normal shear stress-induced inhibition of the proliferation of endothelial cells co-cultured with vascular smooth muscle cells. | Yao, QP., et al. 2013. Cell Physiol Biochem. 31: 389-99. PMID: 23548481
- Schistosoma mansoni Sirtuins: characterization and potential as chemotherapeutic targets. | Lancelot, J., et al. 2013. PLoS Negl Trop Dis. 7: e2428. PMID: 24069483
- Combination of Salermide and Cholera Toxin B Induce Apoptosis in MCF-7 but Not in MRC-5 Cell Lines. | Salahshoor, MR., et al. 2013. Int J Prev Med. 4: 1402-13. PMID: 24498496
- Inhibition of SIRT1/2 upregulates HSPA5 acetylation and induces pro-survival autophagy via ATF4-DDIT4-mTORC1 axis in human lung cancer cells. | Mu, N., et al. 2019. Apoptosis. 24: 798-811. PMID: 31321634
- Inhibition of SIRT1 promotes taste bud stem cell survival and mitigates radiation-induced oral mucositis in mice. | Guo, Q., et al. 2019. Am J Transl Res. 11: 4789-4799. PMID: 31497199
- The role of the Acanthamoeba castellanii Sir2-like protein in the growth and encystation of Acanthamoeba. | Joo, SY., et al. 2020. Parasit Vectors. 13: 368. PMID: 32698828
- A novel chemical-combination screen in zebrafish identifies epigenetic small molecule candidates for the treatment of Duchenne muscular dystrophy. | Farr, GH., et al. 2020. Skelet Muscle. 10: 29. PMID: 33059738
- Myricetin inhibits TNF-α-induced inflammation in A549 cells via the SIRT1/NF-κB pathway. | Chen, M., et al. 2020. Pulm Pharmacol Ther. 65: 102000. PMID: 33601000
- Chronic Exercise Mitigates the Effects of Sirtuin Inhibition by Salermide on Endothelium-Dependent Vasodilation. | Harris, MB., et al. 2021. Cardiovasc Toxicol. 21: 790-799. PMID: 34185244
- SIRT2 and FOXO3a expressions in the cerebral cortex and hippocampus of young and aged male rats: antioxidant and anti-apoptotic effects of melatonin. | Keskin-Aktan, A., et al. 2022. Biol Futur. 73: 71-85. PMID: 34708398
- Comparison of Pronase versus Manual Dechorionation of Zebrafish Embryos for Small Molecule Treatments. | Hasegawa, EH., et al. 2023. J Dev Biol. 11: PMID: 37092478
Inhibitor of:
Esa1, FCP1, HDAC3, Histone H1, Histone H2A.Z, MAFbx, NAT-11, RUNX3, Sir2, Sir3, SIRT1, SIRT2, SIRT4, SIRT5, SIRT7, Sox-9, and YY2.Activator of:
CRSP150_CRSP2, and Sir4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Salermide, 5 mg | sc-224276 | 5 mg | $70.00 | |||
Salermide, 10 mg | sc-224276A | 10 mg | $105.00 |