PTP CD45 Inhibitor: sc-222223. Immunofluorescence staining of methanol-fixed lambda protein phosphatase (sc-200312A) treated (A,B) and PTP CD45 Inhibitor treated (B) NIH/3T3 cells showing nuclear localization and chemical inactivation of lambda phosphatase. Antibody tested: p-NFκB p50 (Ser 337): sc-33022.
PTP CD45 Inhibitor (CAS 345630-40-2)
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Alternate Names:
Protein Tyrosine Phosphatase CD45 Inhibitor; N-(9,10-dihydro-9,10-dioxo-2-phenanthrenyl)-2,2-dimethyl-propanamide
Application:
PTP CD45 Inhibitor is a cell permeable potent reversible inhibitor of CD45
CAS Number:
345630-40-2
Purity:
≥97%
Molecular Weight:
307.34
Molecular Formula:
C19H17NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PTP CD45 Inhibitor is a cell-permeable, potent, selective, competitive, and reversible inhibitor of CD45 (IC50 = 200 nM or 3.8 muM using pNPP or phosphorylated Ick505 peptide as a substrate, respectively). PTP CD45 Inhibitor is not able to effectively inhibit PTPIB (IC50
PTP CD45 Inhibitor (CAS 345630-40-2) References
- Potent reversible inhibitors of the protein tyrosine phosphatase CD45. | Urbanek, RA., et al. 2001. J Med Chem. 44: 1777-93. PMID: 11356112
- GM1 controlled lateral segregation of tyrosine kinase Lck predispose T-cells to cell-derived galectin-1-induced apoptosis. | Novák, J., et al. 2014. Mol Immunol. 57: 302-9. PMID: 24231767
- Cluster of differentiation 45 activation is crucial in interleukin-10-dependent tumor-associated dendritic cell differentiation. | Cheng, DE., et al. 2014. Oncol Lett. 8: 620-626. PMID: 25013476
- T-helper signals restore B-cell receptor signaling in autoreactive anergic B cells by upregulating CD45 phosphatase activity. | Szodoray, P., et al. 2016. J Allergy Clin Immunol. 138: 839-851.e8. PMID: 27056269
- Real-time and high-throughput analysis of mitochondrial metabolic states in living cells using genetically encoded NAD+/NADH sensors. | Zhao, Y. and Yang, Y. 2016. Free Radic Biol Med. 100: 43-52. PMID: 27261194
- Visualization of Nicotine Adenine Dinucleotide Redox Homeostasis with Genetically Encoded Fluorescent Sensors. | Zhao, Y., et al. 2018. Antioxid Redox Signal. 28: 213-229. PMID: 28648094
- The fungal Clitocybe nebularis lectin binds distinct cell surface glycoprotein receptors to induce cell death selectively in Jurkat cells. | Perišić Nanut, M., et al. 2022. FASEB J. 36: e22215. PMID: 35224765
- T-helper cell regulation of CD45 phosphatase activity by galectin-1 and CD43 governs chronic lymphocytic leukaemia proliferation. | Imbery, JF., et al. 2022. Br J Haematol. 198: 556-573. PMID: 35655388
Inhibitor of:
CD45, and PTEN.Activator of:
Gab 3, GBGT1, Krs-1, Maestro, PTEN, Rad23B, and TMEM156.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PTP CD45 Inhibitor, 1 mg | sc-222223A | 1 mg | $104.00 | |||
PTP CD45 Inhibitor, 5 mg | sc-222223 | 5 mg | $306.00 |