Date published: 2026-4-24

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Poly-L-Proline (CAS 25191-13-3)

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CAS Number:
25191-13-3
Molecular Weight:
1,000-10,000
Molecular Formula:
(C5H7NO)n
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Poly-L-proline is a homopolymeric peptide composed of the amino acid proline, linked through peptide bonds in a linear sequence. Its ability to adopt distinct helical conformations makes it an ideal model system for studying the principles of protein folding and the structural preferences of polypeptides under various conditions. Furthermore, the PPII helix, in particular, is of great interest as it is often found in the extended regions of proteins that are involved in signaling and recognition processes.


Poly-L-Proline (CAS 25191-13-3) References

  1. Studies on the structure of poly-L-proline in solution.  |  HARRINGTON, WF. and SELA, M. 1958. Biochim Biophys Acta. 27: 24-41. PMID: 13510248
  2. Interactions between flavan-3-ols and poly(L-proline) studied by isothermal titration calorimetry: effect of the tannin structure.  |  Poncet-Legrand, C., et al. 2007. J Agric Food Chem. 55: 9235-40. PMID: 17850090
  3. Poly(L-proline) II helix propensities in poly(L-lysine) dendrigraft generations from vibrational Raman optical activity.  |  Johannessen, C., et al. 2009. Biomacromolecules. 10: 1662-4. PMID: 19499952
  4. Complexation-Driven Mutarotation in Poly(L-proline) Block Copolypeptides.  |  Gkikas, M., et al. 2015. Biomacromolecules. 16: 3686-93. PMID: 26461162
  5. Thermoresponsive and Mechanical Properties of Poly(L-proline) Gels.  |  Gkikas, M., et al. 2016. Biomacromolecules. 17: 399-406. PMID: 26736072
  6. Measuring the Elasticity of Poly-l-Proline Helices with Terahertz Spectroscopy.  |  Ruggiero, MT., et al. 2016. Angew Chem Int Ed Engl. 55: 6877-81. PMID: 27121300
  7. Oxygen exposure during red wine fermentation modifies tannin reactivity with poly-l-proline.  |  Watrelot, AA., et al. 2019. Food Chem. 297: 124923. PMID: 31253258
  8. Poly(L-proline)-binding proteins from chick embryos are a profilin and a profilactin.  |  Tanaka, M. and Shibata, H. 1985. Eur J Biochem. 151: 291-7. PMID: 3928377
  9. Raman spectroscopy of proline oligomers and poly-L-proline.  |  Rippon, WB., et al. 1970. J Am Chem Soc. 92: 7455-9. PMID: 5487551
  10. A new prolyl hydroxylase acting on poly-L-proline, from suspension cultured cells of Vinca rosea.  |  Tanaka, M., et al. 1980. Biochim Biophys Acta. 616: 188-98. PMID: 6260150
  11. Plant prolyl hydroxylase recognizes poly(L-proline) II helix.  |  Tanaka, M., et al. 1981. J Biol Chem. 256: 11397-400. PMID: 6271746
  12. Interaction of profilin with G-actin and poly(L-proline).  |  Perelroizen, I., et al. 1994. Biochemistry. 33: 8472-8. PMID: 8031780
  13. Isolation and characterization of two mutants of human profilin I that do not bind poly(L-proline).  |  Björkegren-Sjögren, C., et al. 1997. FEBS Lett. 418: 258-64. PMID: 9428724

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Poly-L-Proline, 50 mg

sc-296120
50 mg
$161.00

Poly-L-Proline, 100 mg

sc-296120A
100 mg
$265.00

Poly-L-Proline, 500 mg

sc-296120B
500 mg
$983.00