Molecular structure of PI 3-Kα Inhibitor IV
PI 3-Kα Inhibitor IV
See product citations (2)
Application:
PI 3-Kα Inhibitor IV is a potent and isoform-selective inhibitor of the PI 3-kinase family
Molecular Weight:
386.3
Molecular Formula:
C16H15N3O2S•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
PI 3-Kα Inhibitor IV is a cell-permeable morpholino-thienopyrimidine compound that acts as a potent and isoform-selective inhibitor of PI 3-kinases (IC50 = 2 nM, 16 nM, 660 nM, and 220 nM for p110α, p110β p110γ, and PI 3-K C2β, respectively) and inhibits non-PI 3-K kinases onlyat much higher concentrations (IC50 ≥3.4 μM for Cdk2/E, KDR, PKA, and PKCα). Shown to inhibit cell proliferation (IC50 = 580 nM) and serum-stimulated Akt phosphorylation (IC50
PI 3-Kα Inhibitor IV References
- Synthesis and biological evaluation of 4-morpholino-2-phenylquinazolines and related derivatives as novel PI3 kinase p110alpha inhibitors. | Hayakawa, M., et al. 2006. Bioorg Med Chem. 14: 6847-58. PMID: 16837202
- Investigating dependencies of RAS mutant lung cancer cells[D]., | Lima N S C. 2015.
Inhibitor of:
Enzyme, PI 3-kinase p110 alpha, and PI 3-kinase p110 beta.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PI 3-Kα Inhibitor IV, 5 mg | sc-222170 | 5 mg | $223.00 |