MTH1 Antibody (A-11): sc-373709
- MTH1 Antibody (A-11) is a mouse monoclonal IgG3 κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 87-117 within an internal region of MTH1 of mouse origin
- recommended for detection of MTH1 of mouse and rat origin by WB, IP, IF and ELISA
- m-IgG3 BP-HRP is the preferred secondary detection reagent for MTH1 Antibody (A-11) for WB applications. This reagent is now offered in a bundle with MTH1 Antibody (A-11) (see ordering information below).
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MTH1 Antibody (A-11) is a mouse monoclonal IgG3 antibody that detects MTH1 in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MTH1, also known as NUDT1 (nudix (nucleoside diphosphate linked moiety X)-type motif 1), is a 179 amino acid cytoplasmic protein belonging to the nudix hydrolase family, and plays a crucial role in maintaining genomic integrity by hydrolyzing oxidized purine nucleoside triphosphates into corresponding monophosphates. This enzymatic activity prevents misincorporation of oxidized nucleotides into DNA, thereby averting potentially harmful mutations such as A:T to C:G transversions. The cytoplasmic localization of MTH1 allows effective sanitization of nucleotide pools for both mitochondrial and nuclear genomes, ensuring cellular machinery operates with high fidelity. MTH1 is highly expressed in tissues such as testis, thymus, and proliferating blood lymphocytes, and MTH1 overexpression has been linked to various cancers, including prostate and lung carcinomas. Anti-MTH1 antibody (A-11) serves as an essential tool for researchers investigating MTH1′s role in cellular processes and cancer biology.
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MTH1 Antibody (A-11) References:
- MTH1, an oxidized purine nucleoside triphosphatase, prevents the cytotoxicity and neurotoxicity of oxidized purine nucleotides. | Nakabeppu, Y., et al. 2006. DNA Repair (Amst). 5: 761-72. PMID: 16621731
- Mechanisms of MTH1 inhibition-induced DNA strand breaks: The slippery slope from the oxidized nucleotide pool to genotoxic damage. | Rai, P. and Sobol, RW. 2019. DNA Repair (Amst). 77: 18-26. PMID: 30852368
- MTH1 Inhibitors for the Treatment of Psoriasis. | Bivik Eding, C., et al. 2021. J Invest Dermatol. 141: 2037-2048.e4. PMID: 33676948
- Targeting the DNA repair enzymes MTH1 and OGG1 as a novel approach to treat inflammatory diseases. | Karsten, S. 2022. Basic Clin Pharmacol Toxicol. 131: 95-103. PMID: 35708697
- MTH1 suppression enhances the stemness of MCF7 through upregulation of STAT3. | Li, J., et al. 2022. Free Radic Biol Med. 188: 447-458. PMID: 35809767
- MTH1 Inhibition Alleviates Immune Suppression and Enhances the Efficacy of Anti-PD-L1 Immunotherapy in Experimental Mesothelioma. | Magkouta, SF., et al. 2023. Cancers (Basel). 15: PMID: 37894329
- MTH1 inhibition synergizes with ROS-inducing agents to trigger cervical cancer cells undergoing parthanatos. | Li, C., et al. 2024. Biochim Biophys Acta Mol Basis Dis. 1870: 167190. PMID: 38657912
- Mitotic MTH1 inhibitor TH1579 induces PD-L1 expression and inflammatory response through the cGAS-STING pathway. | Shen, J., et al. 2024. Oncogenesis. 13: 17. PMID: 38796460
- Role of MTH1 in oxidative stress and therapeutic targeting of cancer. | Taiyab, A., et al. 2024. Redox Biol. 77: 103394. PMID: 39418911
- MTH1 in the disorders of the central nervous system: scope beyond brain tumors and challenges. | Padmakumar, L., et al. 2025. Acta Neurol Belg.. PMID: 39960601
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MTH1 Antibody (A-11) | sc-373709 | 200 µg/ml | $322.00 | |||
MTH1 Antibody (A-11): m-IgG3 BP-HRP Bundle | sc-550441 | 200 µg Ab; 40 µg BP | $361.00 | |||
MTH1 (A-11) Neutralizing Peptide | sc-373709 P | 100 µg/0.5 ml | $69.00 |