IOX2 (CAS 931398-72-0)
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IOX2 is a potent and selective inhibitor of the HIF prolyl hydroxylase domain (PHD) enzymes. It functions by binding to the active site of PHD enzymes, preventing the hydroxylation of hypoxia-inducible factor (HIF). This inhibition leads to the stabilization of HIF, allowing it to translocate to the nucleus and activate the transcription of genes involved in cellular adaptation to hypoxia. By modulating the activity of PHD enzymes, IOX2 plays a role in regulating the cellular response to low oxygen levels. Iox2′s mechanism of action involves interfering with the degradation of HIF, ultimately influencing the expression of genes related to angiogenesis, erythropoiesis, and glycolysis. In a development setting, IOX2 is utilized to investigate the molecular pathways involved in cellular responses to hypoxia, providing insights into the mechanisms underlying oxygen sensing and adaptation.
IOX2 (CAS 931398-72-0) References
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IOX2, 5 mg | sc-482692 | 5 mg | $131.00 | |||
IOX2, 25 mg | sc-482692A | 25 mg | $566.00 | |||
IOX2, 100 mg | sc-482692B | 100 mg | $1613.00 |