FTY720 Phosphate CAS: 402615-91-2
MF: C19H34NO5P
MW: 387.50
A derivative of ISP-1 that is a fungal metabolite as well as a structural analog of sphingosine.

FTY720 Phosphate (CAS 402615-91-2)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 122ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
FTY720 Phosphate is rated 5.0 out of 5 by 1.
5
1
4
0
3
0
2
0
1
0
Nomi alternativi: 2- amino- 2[2- (4- octylphenyl)ethyl]- 1, 3- propanediol, mono dihydrogen phosphate ester
Applicazione: FTY720 Phosphate is a derivative of ISP-1 that is a fungal metabolite as well as a structural analog of sphingosine
Numero CAS: 402615-91-2
Purezza: >98%
Peso molecolare: 387.50
Formula molecolare: C19H34NO5P
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).

FTY720 Phosphate is a derivative of ISP-1 (myriocin) that is a fungal metabolite of the Chinese herb Iscaria sinclarii and a structural analog of sphingosine. FTY720 is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. It is phosphorylated by sphingosine kinase to the physiologically active phosphoric acid ester. FTY720 phosphate acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (EDG-1, EDG-3, EDG-4, and EDG-5), with IC50 values of 0.2-6 nM.


Referenze

1 Brinkmann, V., Pinschewer, D.D., Feng, L., et al. FTY720: Altered lymphocyte traffic results in allograft protection. Transplantation 72 764-769 (2001). 2 Brinkmann, V., Davis, M.D., Heise, C.E., et al. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem 277(24) 21453-21457 (2002). 3 Mandala, S., Hajdu, R., Bergstrom, J., et al. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science 296 346-349 (2002). 4 Forrest, M., Sun, S., Hajdu, R., et al. Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes. J Pharmacol Exp Ther 309(2) 758-768 (2004).

Stato fisico :
Solid
Solubilità :
Soluble in chloroform ( ~0.5 mg/ml).
CONSERVAZIONE :
Store at -20° C
Punto di scioglimento :
90.27° C
Punto di ebollizione :
584.24° C at 760 mmHg (Predicted)
Densità :
1.17 g/cm3 (Predicted)
Indice di rifrazione :
n20D 1.54 (Predicted)
IC50 :
EDG-1: IC50 = 0.28 nM (human); EDG-8: IC50 = 0.77 nM (human); EDG-5: IC50 = 0.77 nM (human); EDG-3: IC50 = 6.3 nM (human); EDG-6: IC50 = 15 nM (human)
Valori pK :
pKa: 1.73 (Predicted), pKb: 10.04 (Predicted)
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
PubChem CID :
Numero MDL :
MFCD18251416
SMILES :
CCCCCCCCC1=CC=C(C=C1)CCC(CO)(COP(=O)(O)O)N

Download SDS (MSDS)

CERTIFICATO DI ANALISI

Adobe Acrobat Reader necessario per una visualizzazione affidabile,
stampa e commenta sui documenti PDF

FTY720 Phosphate (CAS 402615-91-2)  Citazioni prodotti

Vedi quanti altri hanno usato FTY720 Phosphate (CAS 402615-91-2). Clicca sulla voce per laccesso a PubMed .

Ciatazioni 1 a5 di 5 totali

PMID: # 27501354  Al Alam, N.|Kreydiyyeh, SI.| et al. 2016. Biochem Cell Biol. 94: 371-7.

PMID: # 24029635  Kraft, P. et al. 2013. Stroke. 44: 3202-10.

PMID: # 24231649  Kajimoto, T. et al. 2013. Nat Commun. 4: 2712.

PMID: # 19619245  Ohno, Y. et al. 2009. Genes Cells. 14: 911-923.

PMID: # 16549044  Chiba, K. et al. 2006. Cell. Mol. Immunol. 3: 11-19.

Ciatazioni 1 a5 di 5 totali
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 110ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 7ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

La Santa Cruz Biotechnology, Inc. è un leader mondiale nello sviluppo di prodotti per il mercato della ricerca biomedica. Chiamaci al numero gratuito 1-800-457-3801.
Copyright © 2007-2021 Santa Cruz Biotechnology, Inc. Tutti i diritti riservati. "Santa Cruz Biotechnology", ed il logo Santa Cruz Biotechnology, Inc."Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", il logo San Juan Ranch, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", ed "EZ Touch" sono marchi registrati dalla Santa Cruz Biotechnology, Inc.
Tutti i marchi sono proprietà dei rispettivi proprietari.