ERp72 Antibody (3): sc-135901
- ERp72 Antibody (3) is a mouse monoclonal IgG1, cited in 1 publications, provided at 50 µg/0.5 ml
- raised against amino acids 427-642 of ERp72 of human origin
- recommended for detection of ERp72 of mouse, rat and human origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ERp72 Antibody (3). This work is in progress.
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ERp72 Antibody (3) is a mouse monoclonal IgG1 antibody that detects ERp72 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). ERp72, also known as protein disulfide-isomerase A4, plays a crucial role in the endoplasmic reticulum by facilitating proper protein folding and disulfide bond rearrangement, which is essential for maintaining protein structure and function. ERp72 is particularly important in the MHC class I antigen presentation pathway, where ERp72 interacts with other chaperones and proteins to ensure MHC class I molecules are correctly assembled before presenting peptides to cytotoxic T lymphocytes. The ability of ERp72 to catalyze the formation and rearrangement of -S-S- bonds is vital for glycoprotein maturation, which is critical for immune responses. Additionally, ERp72′s interactions with other proteins in the ER highlight ERp72′s significance in cellular stress responses and protein quality control, making ERp72 a key player in the immune system′s ability to recognize and respond to intracellular pathogens. Anti-ERp72 antibody (3) is an invaluable tool for researchers studying protein folding and immune responses in various biological contexts.
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ERp72 Antibody (3) References:
- Functional characterization of 3 thioredoxin homology domains of ERp72. | Satoh, M., et al. 2005. Cell Stress Chaperones. 10: 278-84. PMID: 16333982
- Structure of the noncatalytic domains and global fold of the protein disulfide isomerase ERp72. | Kozlov, G., et al. 2009. Structure. 17: 651-9. PMID: 19446521
- ERp72, an abundant luminal endoplasmic reticulum protein, contains three copies of the active site sequences of protein disulfide isomerase. | Mazzarella, RA., et al. 1990. J Biol Chem. 265: 1094-101. PMID: 2295602
- The disulfide isomerase ERp72 supports arterial thrombosis in mice. | Zhou, J., et al. 2017. Blood. 130: 817-828. PMID: 28576878
- A humanized monoclonal antibody that inhibits platelet-surface ERp72 reveals a role for ERp72 in thrombosis. | Holbrook, LM., et al. 2018. J Thromb Haemost. 16: 367-377. PMID: 29052936
- Functional Interplay between P5 and PDI/ERp72 to Drive Protein Folding. | Matsusaki, M., et al. 2021. Biology (Basel). 10: PMID: 34827105
- A novel role for endoplasmic reticulum protein ERp72 in the pathogenesis of autoantibody-induced arthritis. | Yang, A., et al. 2025. Scand J Rheumatol. 54: 16-24. PMID: 38975658
- Several endoplasmic reticulum stress proteins, including ERp72, interact with thyroglobulin during its maturation. | Kuznetsov, G., et al. 1994. J Biol Chem. 269: 22990-5. PMID: 7916014
- Protein degradation by ERp72 from rat and mouse liver endoplasmic reticulum. | Urade, R., et al. 1993. J Biol Chem. 268: 22004-9. PMID: 8408057
- Erp72 expression activated by transient cerebral ischemia or disturbance of neuronal endoplasmic reticulum calcium stores. | Paschen, W., et al. 1998. Metab Brain Dis. 13: 55-68. PMID: 9570640
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ERp72 Antibody (3) | sc-135901 | 50 µg/0.5 ml | $322.00 |