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Epifluorohydrin (CAS 503-09-3)

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Alternate Names:
3-Fluoro-1,2-propenoxide; 1,2-Epoxy-3-fluoropropane
CAS Number:
503-09-3
Molecular Weight:
76.07
Molecular Formula:
C3H5FO
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Epifluorohydrin (EFH) is a versatile and reactive organic compound (VOC) widely employed in various applications, particularly in the production of polymers and plastics. As an essential chemical intermediate, EFH plays a role in synthesizing a variety of fluorinated compounds, including polymers and plastics. This colorless liquid possesses a pungent odor and exhibits slight solubility in water. However, caution is necessary, as EFH′s high reactivity can cause irritation to the eyes and skin. Scientific research has embraced EFH for a diverse array of applications. It has contributed to the synthesis of fluorinated polymers and plastics used in fuel cells, medical implants, and other sectors. Additionally, EFH has been instrumental in the production of agrochemicals, supporting advancements in pest control. EFH′s reactivity extends to a wide range of compounds, including water. Upon contact with water, EFH forms a hydrofluoride ion, which serves as a precursor for generating novel compounds. Furthermore, when interacting with various organic compounds like alcohols and amines, EFH readily participates in forming new compounds. Notably, EFH′s reactivity isn′t limited to organic compounds it can also engage with inorganic substances, such as metals, leading to the creation of additional compounds.


Epifluorohydrin (CAS 503-09-3) References

  1. Characterization of a new pathway for epichlorohydrin degradation by whole cells of xanthobacter strain py2.  |  Small, FJ., et al. 1995. Appl Environ Microbiol. 61: 1507-13. PMID: 16535000
  2. Aqueous-phase aminolysis: approach for the analysis of epoxides in water.  |  Khan, SJ., et al. 2006. Anal Chem. 78: 2608-16. PMID: 16615770
  3. A cold-adapted epoxide hydrolase from a strict marine bacterium, Sphingophyxis alaskensis.  |  Kang, JH., et al. 2008. J Microbiol Biotechnol. 18: 1445-52. PMID: 18756107
  4. Enantioselective binding of structural epoxide isomers by a chiral vanadyl salen complex: a pulsed EPR, cw-ENDOR and DFT investigation.  |  Murphy, DM., et al. 2009. Phys Chem Chem Phys. 11: 6757-69. PMID: 19639150
  5. Infrared spectra and rotational isomerism of epifluorohydrin and other propene oxide derivatives  |  S.W. Charles, G.I.L. Jones, N.L. Owen. 1974. Journal of Molecular Structure. 20: 83-93.
  6. Raman spectra, conformational stability, structural parameters, vibrational assignment, and ab initio calculations for epifluorohydrin  |  H.M Badawi 1, Goran Baranovic 1, P Groner, Mengzhang Zhen, J.R Durig. 1994. Spectrochimica Acta Part A: Molecular Spectroscopy. 50: 383-397.
  7. Conformational stability of epifluorohydrin from temperature dependent FT-IR spectra of xenon solutions and ab initio calculations  |  T.K. Gounev, Seung Won Hur, J.R. Durig. 1998. Journal of Molecular Structure. 449: 241-253.
  8. The rotational spectrum of epifluorohydrin measured by chirped-pulse Fourier transform microwave spectroscopy  |  Gordon G. Brown, Brian C. Dian, Kevin O. Douglass, Scott M. Geyer, Brooks H. Pate. 2006. Journal of Molecular Spectroscopy. 238: 200-212.
  9. Halohydrin dehalogenase-catalysed transformations of epifluorohydrin  |  Maja Majerić Elenkov a, Mirjana Čičak a, Ana Smolko b, Anamarija Knežević a. 2018. Maja Majerić Elenkov a, Mirjana Čičak a, Ana Smolko b, Anamarija Knežević a. 59: 406-408.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Epifluorohydrin, 1 g

sc-257415
1 g
$198.00