CD2 Antibody (TS2/18.1.1): sc-19640
- CD2 Antibody (TS2/18.1.1) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against human cytolytic T lymphocytes
- recommended for detection of CD2 of human origin by WB, IP, IF and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CD2 Antibody (TS2/18.1.1) for WB applications. These reagents are now offered in bundles with CD2 Antibody (TS2/18.1.1) (see ordering information below).
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CD2 Antibody (TS2/18.1.1) is a mouse monoclonal IgG1 antibody that detects CD2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). CD2 is a crucial transmembrane glycoprotein primarily expressed on peripheral blood T lymphocytes, natural killer (NK) cells, and thymocytes, as well as on mouse B cells and rat splenic macrophages. CD2 mediates cell adhesion by interacting with CD58, which enhances antigen-specific T cell activation. This interaction is vital for optimizing immune system recognition, as CD2 facilitates communication between helper T lymphocytes and antigen-presenting cells, as well as between cytolytic effectors and target cells. The importance of CD2 in immune responses underscores CD2′s potential as a therapeutic target in various immunological disorders. Anti-CD2 antibody (TS2/18.1.1) is an essential tool for researchers studying T cell activation and immune system dynamics, providing reliable detection and characterization of CD2 in human samples.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD2 Antibody (TS2/18.1.1) References:
- A subtle role for CD2 in T cell antigen recognition. | van der Merwe, PA. 1999. J Exp Med. 190: 1371-4. PMID: 10562312
- A critical role for p59(fyn) in CD2-based signal transduction. | Fukai, I., et al. 2000. Eur J Immunol. 30: 3507-15. PMID: 11093170
- Quantification and modeling of tripartite CD2-, CD58FC chimera (alefacept)-, and CD16-mediated cell adhesion. | Dustin, ML., et al. 2007. J Biol Chem. 282: 34748-57. PMID: 17911103
- The expression of CD2 in chronic HBV infection. | Li, J., et al. 2008. Cell Mol Immunol. 5: 69-73. PMID: 18318997
- Induction and regulation of CD2 mRNA in human lymphocytes. | Malter, JS., et al. 1988. J Immunol. 140: 3233-6. PMID: 2896216
- CD2 is involved in maintenance and reversal of human alloantigen-specific clonal anergy. | Boussiotis, VA., et al. 1994. J Exp Med. 180: 1665-73. PMID: 7525835
- Alterations of CD2 association with T cell receptor signaling molecules in 'CD2 unresponsive' human T lymphocytes. | Schraven, B., et al. 1993. Eur J Immunol. 23: 119-23. PMID: 8093441
- Down-modulation of CD2 delays deletion of superantigen-responsive T cells. | Fortner, KA., et al. 1998. Eur J Immunol. 28: 70-9. PMID: 9485187
- Differential immunosuppressive activity of monoclonal CD2 antibodies on allograft rejection versus specific antibody production. | Sido, B., et al. 1998. Eur J Immunol. 28: 1347-57. PMID: 9565375
- A p56lck-independent pathway of CD2 signaling involves Jun kinase. | Sunder-Plassmann, R. and Reinherz, EL. 1998. J Biol Chem. 273: 24249-57. PMID: 9727049
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD2 Antibody (TS2/18.1.1) | sc-19640 | 200 µg/ml | $322.00 | |||
CD2 Antibody (TS2/18.1.1): m-IgG Fc BP-HRP Bundle | sc-536626 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD2 Antibody (TS2/18.1.1): m-IgGκ BP-HRP Bundle | sc-533783 | 200 µg Ab; 40 µg BP | $361.00 | |||
CD2 Antibody (TS2/18.1.1): m-IgG1 BP-HRP Bundle | sc-544715 | 200 µg Ab; 20 µg BP | $361.00 | |||
CD2 Antibody (TS2/18.1.1) FITC | sc-19640 FITC | 200 µg/ml | $336.00 | |||
CD2 Antibody (TS2/18.1.1) PE | sc-19640 PE | 200 µg/ml | $349.00 |