Molecular structure of BH3I-1, CAS Number: 300817-68-9
BH3I-1 (CAS 300817-68-9)
Application:
BH3I-1 is a BH3 mimetic that binds to Bcl-xL
CAS Number:
300817-68-9
Purity:
≥97%
Molecular Weight:
400.3
Molecular Formula:
C15H14BrNO3S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
BH3I-1 inhibits a specific protein that is involved in regulating cell growth and survival. This inhibition can lead to the suppression of certain cellular processes, including the proliferation of cancer cells. BH3I-1 disrupts the function of the protein by binding to it and preventing its normal activity. This interference can potentially impact the signaling pathways within the cell, leading to changes in gene expression and cellular behavior. By targeting this protein, BH3I-1 has the potential to affect the balance of cellular processes and may have implications for understanding and potentially manipulating cell function in various biology.
BH3I-1 (CAS 300817-68-9) References
- Enhancement of radiation sensitivity with BH3I-1 in non-small cell lung cancer. | Roa, W., et al. 2005. Clin Invest Med. 28: 55-63. PMID: 15909480
- Chelerythrine and sanguinarine dock at distinct sites on BclXL that are not the classic BH3 binding cleft. | Zhang, YH., et al. 2006. J Mol Biol. 364: 536-49. PMID: 17011577
- Bcl-2 overexpression in thyroid carcinoma cells increases sensitivity to Bcl-2 homology 3 domain inhibition. | Mitsiades, CS., et al. 2007. J Clin Endocrinol Metab. 92: 4845-52. PMID: 17848408
- An intracellular wave of cytochrome c propagates and precedes Bax redistribution during apoptosis. | Lartigue, L., et al. 2008. J Cell Sci. 121: 3515-23. PMID: 18840646
- Computer-assisted identification of small-molecule Bcl-2 modulators. | Füllbeck, M., et al. 2009. Comput Biol Chem. 33: 451-6. PMID: 19889579
- Auto-FACE: an NMR based binding site mapping program for fast chemical exchange protein-ligand systems. | Krishnamoorthy, J., et al. 2010. PLoS One. 5: e8943. PMID: 20174626
- Profiling small molecule inhibitors against helix-receptor interactions: the Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2. | Porter, JR., et al. 2010. Chem Commun (Camb). 46: 8020-2. PMID: 20856941
- Evaluation and critical assessment of putative MCL-1 inhibitors. | Varadarajan, S., et al. 2013. Cell Death Differ. 20: 1475-84. PMID: 23832116
- Inhibition of yeast-to-filamentous growth transitions in Candida albicans by a small molecule inducer of mammalian apoptosis. | Goffena, J., et al. 2018. Yeast. 35: 291-298. PMID: 29048745
- The BH3 mimetic compound BH3I-1 impairs mitochondrial dynamics and promotes stress response in addition to its pro-apoptotic key function. | Stucki, D., et al. 2018. Toxicol Lett. 295: 369-378. PMID: 30031050
- Imbalanced sphingolipid signaling is maintained as a core proponent of a cancerous phenotype in spite of metabolic pressure and epigenetic drift. | Speirs, MMP., et al. 2019. Oncotarget. 10: 449-479. PMID: 30728898
- Mitochondrial Defunctionalization Supresses Tim-3-Galectin-9 Secretory Pathway in Human Colorectal Cancer Cells and Thus Can Possibly Affect Tumor Immune Escape. | Sakhnevych, SS., et al. 2019. Front Pharmacol. 10: 342. PMID: 31024310
- Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp12/7/8 RNA-dependent RNA polymerase. | Bertolin, AP., et al. 2021. Biochem J. 478: 2425-2443. PMID: 34198323
- Interleukin 6 reduces vascular smooth muscle cell apoptosis via Prep1 and is associated with aging. | Cimmino, I., et al. 2021. FASEB J. 35: e21989. PMID: 34679197
- Smad4 and p53 synergize in suppressing autochthonous intestinal cancer. | Park, JW., et al. 2022. Cancer Med. 11: 1925-1936. PMID: 35274815
Inhibitor of:
Bcl-xl.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BH3I-1, 5 mg | sc-221352 | 5 mg | $250.00 |