ATIII Antibody (A-6): sc-393867
- ATIII Antibody (A-6) is a mouse monoclonal IgG3 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 364-395 near the C-terminus of ATIII of human origin
- recommended for detection of ATIII of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG3 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ATIII Antibody (A-6) for WB applications. These reagents are now offered in bundles with ATIII Antibody (A-6) (see ordering information below).
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ATIII Antibody (A-6) is a mouse monoclonal IgG3 antibody that detects Antithrombin III (ATIII) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ATIII is a vital serine protease inhibitor that plays a crucial role in regulating the coagulation cascade, thereby maintaining hemostatic balance in the bloodstream. ATIII primarily functions by inhibiting key proteases such as Thrombin and Factors IXa, Xa, and XIa, which are essential for blood clot formation. ATIII′s importance is underscored by its interaction with heparin, which significantly enhances inhibitory activity, making ATIII a critical component in therapeutic anticoagulation strategies. Deficiencies in ATIII, often due to mutations in the SERPINC1 gene, can lead to serious conditions such as hereditary thrombophilia, highlighting ATIII′s essential role in preventing excessive clotting. Anti-ATIII antibody (A-6) is an invaluable tool for researchers studying coagulation disorders and the mechanisms of blood regulation, providing insights into both normal physiology and pathological conditions.
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ATIII Antibody (A-6) References:
- The complete amino acid sequence of bovine antithrombin (ATIII). | Mejdoub, H., et al. 1991. J Protein Chem. 10: 205-12. PMID: 1930634
- ATIII attenuates endotoxemia induced healing impairment in the colon. | Diller, R., et al. 2009. J Surg Res. 157: 4-13. PMID: 19589540
- Ability of high-affinity heparin fractions with decreasing affinity for antithrombin III to activate ATIII isoforms. | Carlson, TH., et al. 1990. Thromb Res. 59: 521-30. PMID: 2237824
- Molecular characterization of antithrombin III (ATIII) variants using polymerase chain reaction. Identification of the ATIII Charleville as an Ala 384 Pro mutation. | Molho-Sabatier, P., et al. 1989. J Clin Invest. 84: 1236-42. PMID: 2794060
- Antithrombin III Attenuates AKI Following Acute Severe Pancreatitis. | Kong, Y., et al. 2018. Shock. 49: 572-579. PMID: 28719489
- Quantitative and qualitative congenital deficiency of antithrombin III: a new molecular variant called ATIII-Barcelona 2. | Fontcuberta, J., et al. 1988. Thromb Res. 51: 75-81. PMID: 3413737
- Atractylenolide-III alleviates osteoarthritis and chondrocyte senescence by targeting NF-κB signaling. | Xu, Y., et al. 2023. Phytother Res. 37: 4607-4620. PMID: 37380363
- Transfusion studies in patients with familial antithrombin III (ATIII) deficiency: half-disappearance time of infused ATIII and influence of such infusion on platelet life-span. | Winter, JH., et al. 1981. Br J Haematol. 49: 449-53. PMID: 7295588
- Antithrombin III (ATIII) replacement therapy in patients with sepsis and/or postsurgical complications: a controlled double-blind, randomized, multicenter study. | Baudo, F., et al. 1998. Intensive Care Med. 24: 336-42. PMID: 9609411
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ATIII Antibody (A-6) | sc-393867 | 200 µg/ml | $322.00 | |||
ATIII Antibody (A-6): m-IgGκ BP-HRP Bundle | sc-535912 | 200 µg Ab; 40 µg BP | $361.00 | |||
ATIII Antibody (A-6): m-IgG3 BP-HRP Bundle | sc-550315 | 200 µg Ab; 40 µg BP | $361.00 | |||
ATIII (A-6) Neutralizing Peptide | sc-393867 P | 100 µg/0.5 ml | $69.00 |