AT-56 CAS: 162640-98-4
MF: C25H27N5
MW: 397.5

AT-56 (CAS 162640-98-4)

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Applicazione: AT-56 is AT-56 is a prostaglandin D synthase (PGDS) catalyzes the isomerization of PGH2 to produce PGD2.
Numero CAS: 162640-98-4
Peso molecolare: 397.5
Formula molecolare: C25H27N5
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).

Prostaglandin D synthase (PGDS) catalyzes the isomerization of PGH2 to produce PGD2. PGD2 induces sleep, regulates nociception, inhibits platelet aggregation, and acts as an allergic mediator. Two distinct types of PGDS have been identified, namely the lipocalin-type enzyme (β-trace, L-PGDS) and the hematopoietic-type enzyme (H-PGDS). L-PGDS is localized in the central nervous system, male genital organs of various mammals, and the human heart and is a major protein in human cerebrospinal fluid (CSF). AT-56 is a selective, competitive, and highly bioavailable inhibitor of L-PGDS with a Ki i value of 75 µM. It inhibits the production of PGD2 by L-PGDS purified from human CSF and recombinant murine cells with an IC50 value of 95 µM. At concentrations as high as 100 µM in vitro or 30 mg/kg in vivo, AT-56 does not affect the production of PGE2, PGF2α, or H-PGDS-catalyzed PGD2. At 10 mg/kg AT-56, the numbers of total cells, infiltrating eosinophils, and monocytes in bronchoalveolar lavage fluid of L-PGDS transgenic mice were decreased to 23, 6, and 41% of controls, respectively.


Referenze

1. Urade, Y., et al. 1995. J Lipid Mediat Cell Signal 12: 257-273. PMID: 8777570
2. Urade, Y. and Hayaishi, O. 2000. Vitam Horm 58: 89-120. PMID: 1066839
3. Urade, Y. and Eguchi, N. 2002. Prostaglandins Other Lipid Mediat. 68-69: 375-382. PMID: 12432930
4. Irikura, D., et al. 2009. J Biochem. 284: 7623-7630. PMID: 19131342

Stato fisico :
Solid
Solubilità :
Soluble in ethanol (~30 mg/ml), DMSO (~30 mg/ml), DMF (~30 mg/ml), and 1:1 EtOH: PBS (pH 7.2) (~0.5 mg/ml).
CONSERVAZIONE :
Store at -20° C
Punto di scioglimento :
247.04° C (Predicted)
Punto di ebollizione :
~620.4° C at 760 mmHg (Predicted)
Densità :
~1.2 g/cm3 (Predicted)
Indice di rifrazione :
n20D 1.65 (Predicted)
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
WGK Germania :
3
PubChem CID :
11741525

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