ADRM1 Antibody (D-12): sc-271398
- ADRM1 Antibody (D-12) is a mouse monoclonal IgG1 κ ADRM1 antibody provided at 200 µg/ml
- raised against amino acids 1-205 mapping at the N-terminus of ADRM1 of human origin
- ADRM1 Antibody (D-12) is recommended for detection of ADRM1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-ADRM1 Antibody (D-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ADRM1 Antibody (D-12) for WB applications. These reagents are now offered in bundles with ADRM1 Antibody (D-12) (see ordering information below).
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ADRM1 Antibody (D-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects ADRM1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ADRM1 (D-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ADRM1, also known as adhesion-regulating molecule 1, GP110, ARM-1, or Rpn13, consists of 407 amino acids and is primarily localized in both the nucleus and cytoplasm, which is crucial for protein recruitment and cell adhesion. As an integral membrane protein, ADRM1 is essential for recruiting UCH-L5, a deubiquitinating enzyme, to the 26S proteasome, thereby enhancing UCH-L5′s activity and facilitating ubiquitinated protein degradation. ADRM1 plays a key role in mediating lymphocyte adhesion to endothelial cells, suggesting involvement in lymphocyte homing, which is vital for immune response and tissue repair. ADRM1 expression is induced by interferon-gamma in certain cancer cell lines and shows upregulation in various metastatic cells, indicating a potential role in carcinogenesis. Two isoforms of ADRM1 arise from alternative splicing events, which may contribute to diverse functional roles in different cellular contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ADRM1 Antibody (D-12) References:
- Functional cloning of ARM-1, an adhesion-regulating molecule upregulated in metastatic tumor cells. | Simins, AB., et al. 1999. Clin Exp Metastasis. 17: 641-8. PMID: 10919708
- Adhesion properties of adhesion-regulating molecule 1 protein on endothelial cells. | Lamerant, N. and Kieda, C. 2005. FEBS J. 272: 1833-44. PMID: 15819879
- Adrm1, a putative cell adhesion regulating protein, is a novel proteasome-associated factor. | Jørgensen, JP., et al. 2006. J Mol Biol. 360: 1043-52. PMID: 16815440
- Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1. | Yao, T., et al. 2006. Nat Cell Biol. 8: 994-1002. PMID: 16906146
- A Phg2-Adrm1 pathway participates in the nutrient-controlled developmental response in Dictyostelium. | Cherix, N., et al. 2006. Mol Biol Cell. 17: 4982-7. PMID: 16987957
- A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes. | Hamazaki, J., et al. 2006. EMBO J. 25: 4524-36. PMID: 16990800
- hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37. | Qiu, XB., et al. 2006. EMBO J. 25: 5742-53. PMID: 17139257
- Molecular cloning and characterization of the complementary DNA of an M(r) 110,000 antigen expressed by human gastric carcinoma cells and upregulated by gamma-interferon. | Shimada, S., et al. 1994. Cancer Res. 54: 3831-6. PMID: 8033103
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ADRM1 Antibody (D-12) | sc-271398 | 200 µg/ml | $322.00 | |||
ADRM1 Antibody (D-12): m-IgG Fc BP-HRP Bundle | sc-529175 | 200 µg Ab; 10 µg BP | $361.00 | |||
ADRM1 Antibody (D-12): m-IgGκ BP-HRP Bundle | sc-521932 | 200 µg Ab, 40 µg BP | $361.00 | |||
ADRM1 Antibody (D-12) AC | sc-271398 AC | 500 µg/ml, 25% agarose | $424.00 | |||
ADRM1 Antibody (D-12) HRP | sc-271398 HRP | 200 µg/ml | $322.00 | |||
ADRM1 Antibody (D-12) FITC | sc-271398 FITC | 200 µg/ml | $336.00 | |||
ADRM1 Antibody (D-12) PE | sc-271398 PE | 200 µg/ml | $349.00 | |||
ADRM1 Antibody (D-12) Alexa Fluor® 488 | sc-271398 AF488 | 200 µg/ml | $364.00 | |||
ADRM1 Antibody (D-12) Alexa Fluor® 546 | sc-271398 AF546 | 200 µg/ml | $364.00 | |||
ADRM1 Antibody (D-12) Alexa Fluor® 594 | sc-271398 AF594 | 200 µg/ml | $364.00 | |||
ADRM1 Antibody (D-12) Alexa Fluor® 647 | sc-271398 AF647 | 200 µg/ml | $364.00 | |||
ADRM1 Antibody (D-12) Alexa Fluor® 680 | sc-271398 AF680 | 200 µg/ml | $364.00 | |||
ADRM1 Antibody (D-12) Alexa Fluor® 790 | sc-271398 AF790 | 200 µg/ml | $364.00 |