Molecular structure of A 943931 dihydrochloride, CAS Number: 1227675-50-4
A 943931 dihydrochloride (CAS 1227675-50-4)
Application:
A 943931 dihydrochloride is a potent and selective H4 receptor antagonist
CAS Number:
1227675-50-4
Molecular Weight:
368.31
Molecular Formula:
C17H21N5•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
A potent and selective histamine H4 receptor antagonist (pKi values are 7.15 and 8.12 at human and rat receptors respectively). Blocks inflammation in a peritonitis mouse model and displays efficacy in inflammatory pain and neuropathic pain models.
A 943931 dihydrochloride (CAS 1227675-50-4) References
Cowart et al (2008) Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models. J.Med.Chem. 51 6547. Leurs et al (2009) Molecular and biochemical pharmacology of the histamine H4 receptor. Br.J.Pharmacol. 157 14.Inhibitor of:
Histamine H4 Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
A 943931 dihydrochloride, 10 mg | sc-291775 | 10 mg | $205.00 | |||
A 943931 dihydrochloride, 50 mg | sc-291775A | 50 mg | $849.00 |