Ox-LDL R-1 Activators
Ox-LDL R-1 Activators belong to a chemical class of compounds that are involved in the modulation of Oxidized Low-Density Lipoprotein Receptor-1 (Ox-LDL R-1), also known as lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1). Ox-LDL R-1 is a cell surface receptor primarily found on the surface of endothelial cells, smooth muscle cells, and macrophages within blood vessel walls. This receptor plays a pivotal role in the recognition and internalization of oxidized low-density lipoprotein (Ox-LDL) particles, a process that is intimately linked to atherosclerosis, a condition characterized by the buildup of fatty plaques in arteries. Ox-LDL R-1 Activators are small molecules designed to interact with Ox-LDL R-1, influencing its activity or expression, and consequently, the cellular uptake of Ox-LDL particles.
The mechanism of action of Ox-LDL R-1 Activators typically involves binding to specific regions of the Ox-LDL R-1 receptor, inducing conformational changes that may affect its interactions with Ox-LDL molecules or downstream signaling events. By modulating Ox-LDL R-1 activity, these activators influence the recognition and internalization of Ox-LDL particles by vascular cells. Research into Ox-LDL R-1 Activators provides valuable insights into the complex regulatory mechanisms governing lipid metabolism and atherosclerotic plaque formation. Understanding how these activators interact with Ox-LDL R-1 contributes to our knowledge of the intricate processes involved in the development and progression of cardiovascular diseases.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
Pioglitazone, a peroxisome proliferator-activated receptor gamma (PPARγ) agonist, has been found to reduce the expression of OLR1 in vascular endothelial cells. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
Similar to Pioglitazone, Rosiglitazone is a PPARγ agonist that can decrease OLR1 expression, potentially affecting its activity. | ||||||
Atorvastatin | 134523-00-5 | sc-337542A sc-337542 | 50 mg 100 mg | $257.00 $505.00 | 9 | |
A widely known statin, Atorvastatin, can decrease OLR1 expression in endothelial cells, which may influence the receptor’s activity. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $41.00 | 9 | |
Fenofibrate, a PPARα agonist, has been observed to decrease OLR1 expression in certain cellular contexts. | ||||||
DL-α-Tocopherol | 10191-41-0 | sc-294383 sc-294383A sc-294383B sc-294383C | 5 g 25 g 100 g 500 g | $26.00 $52.00 $124.00 $326.00 | 3 | |
DL-α-Tocopherol has antioxidative properties and has been linked to reduced OLR1 expression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
DL-Sulforaphane, found in cruciferous vegetables, has been noted for its potential in downregulating OLR1 expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a polyphenol, has been associated with decreased OLR1 expression. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $27.00 $51.00 $101.00 $153.00 $1925.00 | 40 | |
Luteolin, another flavonoid, has been reported to influence OLR1 expression. | ||||||
Nicotinic Acid | 59-67-6 | sc-205768 sc-205768A | 250 g 500 g | $62.00 $124.00 | 1 | |
Nicotinic Acid has been shown to have an effect on OLR1 expression, potentially influencing its activity. | ||||||