OTTMUSG00000016644 Activators
Interferon-induced protein with tetratricopeptide repeats 1B like 1 isoform X2 (Ifit1bl1) is a vital component of the innate immune response system. This protein is induced by interferons and plays a significant role in antiviral defense mechanisms. Ifit1bl1 is known for its role in recognizing viral nucleic acids and inhibiting viral replication. It contains tetratricopeptide repeat (TPR) domains that enable its interactions with various cellular and viral proteins. Activation of Ifit1bl1 primarily occurs in response to interferon signaling. Interferons, such as Interferon-α and IFN-β, directly activate Ifit1bl1 by binding to their respective receptors and initiating the JAK-STAT signaling pathway. This leads to the functional activation of Ifit1bl1, which subsequently exerts its antiviral effects by inhibiting viral RNA translation and replication. Additionally, other chemicals like Poly(I:C) and Imiquimod indirectly activate Ifit1bl1 by stimulating Toll-like receptors (TLRs), triggering an immune response and upregulating the protein's expression.
In conclusion, Ifit1bl1 is a key player in the innate immune response against viral infections. Its activation is tightly regulated by interferons and TLRs, ensuring a rapid and effective antiviral defense mechanism. Understanding the activation mechanisms of Ifit1bl1 provides valuable insights into the host's ability to combat viral pathogens.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Polyinosinic acid - polycytidylic acid sodium salt, double-stranded | 42424-50-0 | sc-204854 sc-204854A | 10 mg 100 mg | $139.00 $663.00 | 2 | |
Poly(I:C) acts as an indirect activator by stimulating Toll-like receptors (TLRs), triggering the innate immune response. This, in turn, leads to the upregulation and functional activation of the target protein. | ||||||
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $251.00 $500.00 $547.00 | 16 | |
Ruxolitinib activates the protein indirectly by inhibiting JAK1 and JAK2 kinases, preventing their phosphorylation and downstream signaling, resulting in increased expression and functional activation of the target protein. | ||||||
Imiquimod | 99011-02-6 | sc-200385 sc-200385A | 100 mg 500 mg | $67.00 $284.00 | 6 | |
Imiquimod indirectly activates the protein by stimulating Toll-like receptor 7 (TLR7), which triggers an immune response, ultimately leading to the upregulation and functional activation of the target protein. | ||||||
JAK Inhibitor I | 457081-03-7 | sc-204021 sc-204021A | 500 µg 1 mg | $156.00 $339.00 | 59 | |
JAK Inhibitor I activates the protein indirectly by inhibiting JAK1 and JAK2 kinases, preventing their phosphorylation and downstream signaling, resulting in increased expression and functional activation of the target protein. | ||||||
Polyuridylic acid potassium salt | 27416-86-0 | sc-215733 sc-215733A | 10 mg 25 mg | $189.00 $343.00 | 2 | |
Poly(U) acts as an indirect activator by stimulating Toll-like receptors (TLRs), triggering the innate immune response. This, in turn, leads to the upregulation and functional activation of the target protein. | ||||||
Stat3 Inhibitor III, WP1066 | 857064-38-1 | sc-203282 | 10 mg | $132.00 | 72 | |
WP1066 activates the protein indirectly by inhibiting STAT3 phosphorylation and its downstream signaling, resulting in increased expression and functional activation of the target protein. | ||||||
LY 303511 | 154447-38-8 | sc-202215 sc-202215A | 1 mg 5 mg | $67.00 $278.00 | 3 | |
NF-κB Activator indirectly activates the protein by promoting NF-κB signaling, which enhances the expression and functional activation of interferon-induced protein with tetratricopeptide repeats 1B like 1 isoform X2. | ||||||