MTP Activators
MTP Activators are a class of chemical compounds that influence lipid metabolism and the function of Microsomal Triglyceride Transfer Protein (MTP) through their actions on specific cellular pathways. These compounds include GW501516 (Cardarine), AICAR, Metformin, resveratrol, fenofibrate, betaine, berberine, cholic acid, omega-3 fatty acids, L-carnitine, bezafibrate, and citrus flavonoids. Each of these chemicals can indirectly activate or modulate MTP by targeting various biochemical or cellular processes. GW501516 activates peroxisome proliferator-activated receptor delta (PPARδ), a nuclear receptor involved in lipid metabolism. PPARδ activation can lead to the modulation of genes related to lipid transport and metabolism, enhancing MTP activity. AICAR and Metformin activate AMP-activated protein kinase (AMPK), a key regulator of cellular energy status and lipid metabolism. The activation of AMPK can promote lipid oxidation and influence various aspects of lipid metabolism, indirectly supporting MTP function. Thyroid hormones, specifically T3, regulate genes involved in lipid transport and metabolism, indirectly affecting MTP function by modulating overall lipid metabolism within cells.
Resveratrol activates SIRT1, a protein deacetylase involved in cellular metabolism. SIRT1 activation can impact lipid metabolism, leading to indirect effects on MTP function. Fenofibrate and bezafibrate are PPARα activators that can change gene expression related to lipid metabolism, indirectly influencing MTP activity. Betaine, an osmolyte, influences lipid metabolism, and although its mechanism is not fully elucidated, it may impact MTP indirectly through its effects on lipid metabolism. Berberine activates AMPK, similar to AICAR and Metformin, influencing lipid metabolism and cellular energy regulation, enhancing MTP activity. Cholic acid, a bile acid, regulates lipid absorption in the intestine. Its effects on lipid absorption and metabolism can indirectly influence MTP activity by altering the availability of lipids for transport and assembly into lipoproteins. Omega-3 fatty acids, such as EPA and DHA, modulate lipid metabolism at multiple levels, impacting MTP indirectly by influencing the availability and handling of lipids in cells. L-carnitine is involved in fatty acid transport and oxidation, indirectly activating MTP by influencing the transport and utilization of fatty acids, essential for the assembly of lipoproteins.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
GW501516 | 317318-70-0 | sc-202642 sc-202642A | 1 mg 5 mg | $82.00 $179.00 | 28 | |
GW501516 is an agonist of PPARδ, a nuclear receptor that regulates genes involved in lipid metabolism. Activation of PPARδ can lead to the modulation of gene expression related to lipid transport and metabolism, potentially indirectly activating MTP function. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR is an AMPK activator. AMPK plays a crucial role in cellular energy regulation and lipid metabolism. Activation of AMPK can promote lipid oxidation and influence various aspects of lipid metabolism, which may indirectly activate MTP activity. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Metformin is another AMPK activator commonly used to treat type 2 diabetes. It can influence cellular energy status and lipid metabolism through AMPK activation, potentially leading to indirect activation on MTP function. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is known to activate SIRT1, a protein deacetylase involved in cellular metabolism. SIRT1 activation can impact various aspects of lipid metabolism, potentially leading to activation of MTP function within the context of cellular lipid handling. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $41.00 | 9 | |
Fenofibrate is an agent in research that activates PPARα, a nuclear receptor associated with lipid metabolism. Its activation can lead to changes in gene expression related to lipid transport and metabolism, potentially indirectly activating MTP activity. | ||||||
Betaine | 107-43-7 | sc-214595 sc-214595A sc-214595B sc-214595C sc-214595D sc-214595E | 50 g 100 g 250 g 1 kg 2.5 kg 5 kg | $31.00 $41.00 $56.00 $163.00 $337.00 $592.00 | 2 | |
Betaine is an osmolyte known to influence lipid metabolism. While the exact mechanism is not fully elucidated, betaine has been associated with improved lipid profiles, potentially activating MTP indirectly through its effects on lipid metabolism. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine hydrochloride can activate AMPK, similar to AICAR and metformin. AMPK activation by berberine can influence lipid metabolism and cellular energy regulation, potentially leading to indirect activation on MTP activity. | ||||||
Cholic acid | 81-25-4 | sc-255020 sc-255020A sc-255020B sc-255020C sc-255020D | 25 g 100 g 500 g 1 kg 5 kg | $49.00 $123.00 $578.00 $1018.00 $4570.00 | 11 | |
Cholic acid is a bile acid that regulates lipid absorption in the intestine. Its effects on lipid absorption and metabolism can indirectly activate MTP activity by altering the availability of lipids for transport and assembly into lipoproteins. | ||||||
L-Carnitine | 541-15-1 | sc-205727 sc-205727A sc-205727B sc-205727C | 1 g 5 g 100 g 250 g | $23.00 $34.00 $79.00 $179.00 | 3 | |
L-carnitine is involved in fatty acid transport and oxidation. Its role in lipid metabolism can indirectly affect MTP by activating the transport and utilization of fatty acids, which are essential for the assembly of lipoproteins by MTP. | ||||||
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $31.00 $46.00 $122.00 $204.00 | 5 | |
Bezafibrate is a fibrate agent in research that activates PPARα, similar to fenofibrate. Activation of PPARα can lead to changes in gene expression related to lipid metabolism, potentially indirectly activating MTP activity by modulating lipid transport and metabolism. | ||||||