IPMK Activators
IPMK activators constitute a category of chemical agents that enhance the activity of Inositol Polyphosphate Multikinase (IPMK), a vital enzyme that plays a multifaceted role in cellular signaling by phosphorylating inositol phosphates. IPMK is not only a key enzyme in the phosphoinositide signaling pathway but also acts as a coactivator for certain transcription factors, thus influencing gene expression. The activation of IPMK is significant for its involvement in the synthesis of inositol triphosphate (IP3) and other higher-order inositol phosphates, which are critical for intracellular signaling cascades.
Direct activators of IPMK may interact with the enzyme at its active site or allosteric sites, modulating its catalytic activity. Such binding could induce a conformational shift that enhances the enzyme's substrate affinity or catalytic efficiency, leading to increased production of inositol phosphates. This upregulation of enzymatic function can amplify the signaling pathways in which these molecules are involved, such as those regulating calcium release from intracellular stores and subsequent cellular responses. Indirect activators operate by affecting IPMK activity through modulation of upstream or downstream factors. These could include the upregulation of IPMK expression through transcriptional activation, stabilization of IPMK mRNA, or inhibition of degradation pathways targeting the IPMK protein, thereby increasing its cellular abundance. Additionally, indirect activators may influence the availability of substrates or cofactors necessary for IPMK's enzymatic reactions, or they might modulate the activity of interacting proteins that affect IPMK's function.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
BAPTA-AM is a cell-permeable Ca2+ chelator. Upon entry into cells, it is hydrolyzed by intracellular esterases to BAPTA, which binds to free Ca2+ ions. This can indirectly enhance IPMK activity through the Ca2+-calmodulin pathway as IPMK is known to be activated by Ca2+-calmodulin. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole is a known microtubule-disrupting agent that induces mitotic arrest. Microtubule disruption can indirectly enhance IPMK activity by causing cellular stress, leading to increased Ca2+ levels, and thus activating the Ca2+-calmodulin pathway which is known to activate IPMK. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a non-competitive inhibitor of the sarco-/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to an increase in cytosolic Ca2+ concentration. The elevation in Ca2+ concentration can activate the Ca2+-calmodulin pathway that activates IPMK. | ||||||
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $176.00 $624.00 | 3 | |
Cyclopiazonic acid is a specific inhibitor of the sarco-/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to an increase in cytosolic Ca2+ concentration. The elevation in Ca2+ concentration can activate the Ca2+-calmodulin pathway which is known to activate IPMK. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
2-APB is an inositol 1,4,5-trisphosphate receptor (IP3R) modulator. It can indirectly enhance IPMK activity by modulating IP3R-mediated Ca2+ release, leading to increased intracellular Ca2+ levels that can activate the Ca2+-calmodulin pathway which is known to activate IPMK. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $103.00 $158.00 $397.00 $656.00 | 2 | |
SKF-96365 is an inhibitor of receptor-mediated calcium entry (RMCE). It can indirectly enhance IPMK activity by modulating intracellular Ca2+ levels, thus activating the Ca2+-calmodulin pathway which is known to activate IPMK. | ||||||
Xestospongin C | 88903-69-9 | sc-201505 | 50 µg | $510.00 | 14 | |
Xestospongin C is a potent inhibitor of IP3 receptor. By inhibiting the IP3 receptor, it can increase intracellular Ca2+ levels, thus indirectly enhancing IPMK activity via the Ca2+-calmodulin pathway. | ||||||
Ryanodine | 15662-33-6 | sc-201523 sc-201523A | 1 mg 5 mg | $223.00 $799.00 | 19 | |
Ryanodine is a plant alkaloid that modifies the function of ryanodine receptors, thereby affecting intracellular Ca2+ levels. This can indirectly enhance IPMK activity via the Ca2+-calmodulin pathway. | ||||||
TMB-8 • HCl | 53464-72-5 | sc-3522 sc-3522A | 10 mg 50 mg | $43.00 $129.00 | 10 | |
TMB-8 is an inhibitor of intracellular Ca2+ release. By modifying intracellular Ca2+ levels, it can indirectly enhance IPMK activity via the Ca2+-calmodulin pathway. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin is a calcium ionophore that can increase intracellular Ca2+ levels. This can indirectly enhance IPMK activity via the Ca2+-calmodulin pathway. | ||||||