IκB-ε Activators
The chemical class known as IκB-ε Activators represents a unique group of molecules that interact with the NF-κB signaling pathway, specifically targeting the IκB-ε protein. This class is distinguished by its ability to modulate the activity of IκB-ε, a member of the IκB family of proteins. These proteins are pivotal in the NF-κB signaling pathway, a critical regulator of immune response, cell survival, and proliferation. The NF-κB pathway is known for its role in controlling the transcription of DNA, cytokine production, and cell survival. The IκB proteins, including IκB-ε, act as inhibitors of NF-κB by sequestering NF-κB in the cytoplasm, thus preventing its entry into the nucleus where it can influence gene expression.
IκB-ε Activators function by modulating the activity of IκB-ε, leading to alterations in the NF-κB pathway. Unlike other members of the IκB family, such as IκBα and IκBβ, IκB-ε has unique regulatory features and expression patterns, making the activators of this protein particularly interesting. The activation of IκB-ε leads to a cascade of events, including its phosphorylation, ubiquitination, and subsequent degradation. This degradation process frees NF-κB, allowing it to translocate to the nucleus.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane, found in cruciferous vegetables, activates the Nrf2 pathway which can modulate the NF-κB pathway. This modulation can indirectly lead to the activation of IκB-ε by altering the cellular redox state and influencing inflammatory responses. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid found in many fruits and vegetables, is known to interfere with the NF-κB pathway, potentially through its antioxidant properties, which can indirectly influence the activity of IκB-ε. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a major green tea catechin, can modulate the NF-κB pathway. Its antioxidant properties contribute to changes in NF-κB activity, which indirectly influences IκB-ε. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin, found in chili peppers, can affect NF-κB signaling. This influence is potentially through sensory neurons and their mediators, which can lead to changes in IκB-ε activity. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine can influence several signaling pathways, including NF-κB. Its ability to modulate cellular stress responses can indirectly impact IκB-ε activity. | ||||||
Docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic Acid (22:6, n-3) | 6217-54-5 | sc-200768 sc-200768A sc-200768B sc-200768C sc-200768D | 100 mg 1 g 10 g 50 g 100 g | $94.00 $210.00 $1779.00 $8021.00 $16657.00 | 11 | |
Omega-3 fatty acids, found in fish oil, can modulate inflammatory responses via the NF-κB pathway. This modulation has implications for IκB-ε activity due to the central role of NF-κB in inflammation. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Vitamin D3 can modulate immune responses, partially through the NF-κB pathway. This modulation can have downstream effects on IκB-ε due to its role in regulating NF-κB activity. | ||||||
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $42.00 | 4 | |
Aspirin can modulate the NF-κB pathway through its anti-inflammatory action, which can indirectly impact IκB-ε activity. | ||||||
Sodium Salicylate | 54-21-7 | sc-3520 sc-3520A sc-3520B sc-3520C | 1 g 25 g 500 g 1 kg | $10.00 $26.00 $82.00 $139.00 | 8 | |
Sodium Salicylate, similar to aspirin, affects the NF-κB pathway. This influence can alter IκB-ε activity, as it is part of the regulatory mechanism for NF-κB. | ||||||