ERC2 Activators
ERC2, also known as ELKS/RAB6-interacting/CAST family member 2, is a protein encoded by the ERC2 gene in humans. It's part of the ELKS/RAB6-interacting/CAST family of proteins, which play a significant role in the regulation of exocytosis, a process critical for the release of neurotransmitters at synaptic terminals in neurons.The ERC2 protein is predominantly found in the brain and is a component of the active zone, a specialized area of the presynaptic membrane where synaptic vesicles dock and fuse to release neurotransmitters. ERC2 interacts with several other active zone proteins and plays a crucial role in maintaining the structure and function of the active zone.
One of the key interactions of ERC2 is with another protein called RIM (Rab3 Interacting Molecule). This interaction is essential for the assembly and stabilization of the active zone and the regulation of neurotransmitter release.Furthermore, ERC2 plays a role in vesicle trafficking. It's suggested to be involved in the transport of synaptic vesicles and the regulation of their release, critical for neurotransmission.Research has suggested that mutations or dysregulation of ERC2 or other members of the ELKS/RAB6-interacting/CAST family could potentially contribute to neurological disorders, including autism spectrum disorders and schizophrenia. However, the precise mechanisms by which ERC2 might contribute to these conditions are not fully understood.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid modulates gene expression during neural development, potentially influencing genes involved in synaptic assembly and function. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin elevates cAMP, which may lead to the activation of CREB, a transcription factor that could induce ERC2 expression as part of synaptic modulation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Phorbol esters activate protein kinase C (PKC), which is implicated in a variety of neural processes including modulation of synaptic proteins. | ||||||
Fluoxetine | 54910-89-3 | sc-279166 | 500 mg | $318.00 | 9 | |
Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) that may affect synaptic plasticity and potentially the expression of ERC2. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium affects several signaling pathways and has been shown to impact neural plasticity and neurogenesis, possibly influencing ERC2 expression. | ||||||
Kainic acid monohydrate | 58002-62-3 | sc-269283 | 10 mg | $275.00 | ||
Kainic acid is an agonist of the glutamate receptor and can induce synaptic activity, potentially affecting the expression of synaptic proteins. | ||||||
N-Methyl-D-Aspartic acid (NMDA) | 6384-92-5 | sc-200458 sc-200458A | 50 mg 250 mg | $109.00 $369.00 | 2 | |
NMDA receptor activation is pivotal in synaptic plasticity, and its activation might influence the expression of related synaptic proteins. | ||||||
Glycine | 56-40-6 | sc-29096A sc-29096 sc-29096B sc-29096C | 500 g 1 kg 3 kg 10 kg | $41.00 $71.00 $112.00 $357.00 | 15 | |
Glycine acts as an inhibitory neurotransmitter and also as a co-agonist of NMDA receptors, which could modulate synaptic protein expression. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
This cAMP analog can passively enter cells and elevate the intracellular cAMP level, potentially affecting CREB activity and ERC2 expression. | ||||||