DUB1A Activators
Usp17lb, a thiol-dependent deubiquitinase, plays a crucial role in protein deubiquitination and is predicted to be located in the endoplasmic reticulum membrane, active in the cytosol and nucleus. The protein exhibits orthology to several human genes, including USP17L10, USP17L11, and USP17L12. Understanding the activation mechanisms of Usp17lb involves exploring direct and indirect activators that modulate its thiol-dependent deubiquitinase activity. Direct activators like ML323, HBX 41108, and PR-619 specifically target Usp17lb, directly down-regulating its activity by inhibiting the thiol-dependent deubiquitinase function. On the other hand, indirect activators such as P22077 and WP1130 influence the broader ubiquitin-proteasome system, indirectly up-regulating Usp17lb by preventing its deubiquitination. Compounds like EOAI3402143 and IU1-47 target USP14, indirectly promoting Usp17lb by preventing its deubiquitination.
Furthermore, derivatives like HBX 19818 derivative 2 and FT671 showcase the specificity of inhibition towards Usp17lb, providing additional avenues for direct modulation. VLX1570 and its analog, proteasome deubiquitinase inhibitors, indirectly up-regulate Usp17lb by influencing the broader ubiquitin-proteasome system. The activation of Usp17lb is intricately linked to its thiol-dependent deubiquitinase activity, which is targeted by these compounds. The identified activators offer specific avenues for influencing Usp17lb function and stability, contributing to a comprehensive understanding of its role in protein deubiquitination.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
P22077 | 1247819-59-5 | sc-478536 | 10 mg | $165.00 | ||
P22077, a small molecule inhibitor of USP7, indirectly activates Usp17lb by preventing its deubiquitination. By inhibiting USP7, P22077 influences the ubiquitin landscape, indirectly up-regulating Usp17lb. The compound's impact on the thiol-dependent deubiquitinase pathway provides a specific mechanism for modulating Usp17lb through intricate interactions with the broader ubiquitin-proteasome system. P22077 offers a unique avenue for promoting the stability of Usp17lb and influencing its cellular functions. | ||||||
PR 619 | 2645-32-1 | sc-476324 sc-476324A sc-476324B | 1 mg 5 mg 25 mg | $77.00 $188.00 $431.00 | 1 | |
PR-619, a broad-spectrum DUB inhibitor, directly down-regulates Usp17lb activity. By inhibiting thiol-dependent deubiquitinases, including USP17, PR-619 specifically targets Usp17lb, leading to decreased protein deubiquitination. This direct modulation of USP17 activity provides a unique avenue for influencing Usp17lb function and stability in cellular contexts. PR-619 offers a broad-spectrum approach for down-regulating Usp17lb activity through targeted inhibition of DUBs. | ||||||
WP1130 | 856243-80-6 | sc-364650 sc-364650A | 10 mg 50 mg | $490.00 $1484.00 | 1 | |
WP1130, a deubiquitinase (DUB) inhibitor, directly down-regulates Usp17lb activity. By inhibiting DUBs, including USP17, WP1130 specifically targets Usp17lb, leading to decreased protein deubiquitination. This direct modulation of USP17 activity provides a unique avenue for influencing Usp17lb function and stability in cellular contexts. WP1130 offers a specific approach for down-regulating Usp17lb activity through targeted inhibition of DUBs. | ||||||
IU1 | 314245-33-5 | sc-361215 sc-361215A sc-361215B | 10 mg 50 mg 100 mg | $138.00 $607.00 $866.00 | 2 | |
IU1-47, an inhibitor of USP14, indirectly up-regulates Usp17lb by preventing its deubiquitination. By inhibiting USP14, IU1-47 influences the ubiquitin landscape, indirectly promoting Usp17lb. The compound's impact on the thiol-dependent deubiquitinase pathway provides a specific mechanism for modulating Usp17lb through intricate interactions with the broader ubiquitin-proteasome system. IU1-47 offers a unique avenue for promoting the stability of Usp17lb and influencing its cellular functions. | ||||||