Clb2 Activators
Clb2, a cyclin protein found in the budding yeast Saccharomyces cerevisiae, serves as a critical regulator of the cell cycle, particularly during the transition from the G2 to M phase. Functionally, Clb2 forms complexes with cyclin-dependent kinases (CDKs), notably Clb2-Cdc28 complexes, which drive cell cycle progression by phosphorylating target proteins involved in various cellular processes. Specifically, Clb2-Cdc28 complexes promote entry into mitosis by phosphorylating key substrates that regulate nuclear envelope breakdown, spindle assembly, and chromosome segregation. Moreover, Clb2 plays a significant role in coordinating DNA replication, DNA repair, and spindle assembly checkpoint activation, ensuring the fidelity of cell division and maintenance of genome stability. Through its pivotal role in cell cycle regulation, Clb2 orchestrates the orderly progression of cell division events, ensuring proper cell growth and proliferation.
Activation of Clb2 is tightly regulated through a series of intricate mechanisms aimed at promoting its association with CDKs and facilitating cell cycle progression. Various signals and checkpoints within the cell cycle pathway regulate the activation of Clb2. Notably, the expression of Clb2 is controlled by transcriptional and post-translational mechanisms, ensuring its timely accumulation during the cell cycle. Additionally, Clb2 activity is modulated by phosphorylation events mediated by upstream kinases, which enhance its binding to CDKs and promote the formation of active Clb2-Cdc28 complexes. Furthermore, Clb2 activation is coordinated with the progression of other cell cycle events, such as DNA replication and checkpoint signaling, ensuring proper coordination and synchronization of cell division processes. Understanding the detailed mechanisms underlying Clb2 activation provides insights into the regulation of cell cycle dynamics and offers targets for intervention in diseases characterized by dysregulated cell proliferation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
CGP-60474 | 164658-13-3 | sc-507525 | 5 mg | $165.00 | ||
CGP 60474 is a chemical compound that acts as a direct activator of Clb2 by promoting the activation of cyclin-dependent kinases (CDKs). As a CDK activator, CGP 60474 enhances the cell cycle progression by facilitating the activation of CDKs, including Clb2. This direct activation reinforces the regulatory function of Clb2 in the cell cycle, leading to improved cell cycle dynamics and increased cellular proliferation. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $259.00 | 41 | |
Flavopiridol is a chemical compound that serves as a direct activator of Clb2 by promoting the activation of cyclin-dependent kinases (CDKs). As a CDK activator, Flavopiridol enhances the cell cycle progression by facilitating the activation of CDKs, including Clb2. This direct activation reinforces the regulatory function of Clb2 in the cell cycle, leading to improved cell cycle dynamics and increased cellular proliferation. | ||||||
RGB-286638 | 784210-88-4 | sc-507523 | 250 mg | $285.00 | ||
RGB-286638 is a chemical compound that acts as a direct activator of Clb2 by promoting the activation of cyclin-dependent kinases (CDKs). As a CDK activator, RGB-286638 enhances the cell cycle progression by facilitating the activation of CDKs, including Clb2. This direct activation reinforces the regulatory function of Clb2 in the cell cycle, leading to improved cell cycle dynamics and increased cellular proliferation. | ||||||
PHA-848125 | 802539-81-7 | sc-364581 sc-364581A | 5 mg 10 mg | $304.00 $555.00 | ||
PHA-848125 is a chemical compound that serves as a direct activator of Clb2 by promoting the activation of cyclin-dependent kinases (CDKs). As a CDK activator, PHA-848125 enhances the cell cycle progression by facilitating the activation of CDKs, including Clb2. This direct activation reinforces the regulatory function of Clb2 in the cell cycle, leading to improved cell cycle dynamics and increased cellular proliferation. | ||||||
Flubendazole | 31430-15-6 | sc-204754 sc-204754A | 10 g 25 g | $97.00 $158.00 | 3 | |
Flubendazole is a chemical compound that serves as a direct activator of Clb2 by promoting the activation of cyclin-dependent kinases (CDKs). As a CDK activator, Flubendazole enhances the cell cycle progression by facilitating the activation of CDKs, including Clb2. This direct activation reinforces the regulatory function of Clb2 in the cell cycle, leading to improved cell cycle dynamics and increased cellular proliferation. | ||||||
AZD 5438 | 602306-29-6 | sc-361115 sc-361115A | 10 mg 50 mg | $205.00 $865.00 | ||
AZD5438 is a chemical compound that acts as a direct activator of Clb2 by promoting the activation of cyclin-dependent kinases (CDKs). As a CDK activator, AZD5438 enhances the cell cycle progression by facilitating the activation of CDKs, including Clb2. This direct activation reinforces the regulatory function of Clb2 in the cell cycle, leading to improved cell cycle dynamics and increased cellular proliferation. | ||||||