C130074G19Rik Activators
C130074G19Rik, predicted to be located in 9+0 non-motile cilia, is orthologous to human C1orf115, suggesting a conserved role in cellular structures associated with cilia. The gene's potential function within these structures makes it a candidate of interest for understanding ciliary biology. Activation of C130074G19Rik involves a variety of chemicals influencing specific pathways or cellular processes. Lithium chloride, a GSK-3β inhibitor, stabilizes β-catenin, potentially influencing Wnt signaling and indirectly activating C130074G19Rik. Forskolin activates C130074G19Rik through the cAMP-PKA pathway, offering insight into its responsiveness to cyclic AMP signaling. Retinoic acid and sodium butyrate, by modulating differentiation and histone deacetylation, respectively, could indirectly impact C130074G19Rik through epigenetic regulation. Ciliary neurotrophic factor (CNTF) engages the JAK-STAT pathway, linking C130074G19Rik to this signaling cascade. Sonic Hedgehog (SHH) activates C130074G19Rik through Hedgehog signaling, suggesting a potential role in developmental processes.
Furthermore, chemicals like Tauroursodeoxycholic acid (TUDCA) and chlorogenic acid highlight potential connections to endoplasmic reticulum stress and antioxidant responses, respectively. Prostaglandin E2, sulforaphane, and valproic acid, acting through distinct pathways, offer additional insights into the complex regulation of C130074G19Rik. Lastly, 2-deoxyglucose, influencing AMPK activation, suggests a connection between C130074G19Rik and cellular energy sensing. Understanding the activation of C130074G19Rik sheds light on its potential involvement in cellular processes associated with non-motile cilia. The diverse range of activators and pathways implicated in its regulation underscores the intricate nature of C130074G19Rik's function within these structures. Further exploration of these mechanisms may provide valuable contributions to the understanding of ciliary biology and associated cellular processes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride induces C130074G19Rik activation by modulating Wnt signaling. As a GSK-3β inhibitor, it stabilizes β-catenin, influencing Wnt pathway activation. C130074G19Rik, orthologous to C1orf115, may be indirectly activated as part of the Wnt signaling cascade. Lithium chloride impacts the biochemical pathway by inhibiting GSK-3β, leading to β-catenin stabilization, and potentially influencing C130074G19Rik in non-motile cilia. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid influences C130074G19Rik via retinoic acid receptors, modulating cellular differentiation. As a retinoid, it binds to receptors, affecting gene expression. C130074G19Rik, orthologous to C1orf115, might be indirectly activated by retinoic acid, as part of a differentiation program. Retinoic acid modulates cellular processes, leading to potential C130074G19Rik activation in structures associated with 9+0 non-motile cilia. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate influences C130074G19Rik through histone deacetylase inhibition. As an HDAC inhibitor, it alters chromatin structure, potentially impacting C130074G19Rik expression. C130074G19Rik, orthologous to C1orf115, might be indirectly activated as part of epigenetic regulation. Sodium butyrate modulates histone deacetylation, leading to potential C130074G19Rik activation in structures associated with 9+0 non-motile cilia. | ||||||
Tauroursodeoxycholic Acid, Sodium Salt | 14605-22-2 | sc-281165 | 1 g | $644.00 | 5 | |
Tauroursodeoxycholic Acid, Sodium Salt influences C130074G19Rik through endoplasmic reticulum (ER) stress modulation. Acting as an ER chaperone, it reduces stress, potentially impacting C130074G19Rik function. | ||||||
Chlorogenic Acid | 327-97-9 | sc-204683 sc-204683A | 500 mg 1 g | $47.00 $69.00 | 1 | |
Chlorogenic acid activates C130074G19Rik through the Keap1-Nrf2 pathway. As a Keap1-Nrf2 activator, it influences antioxidant responses, potentially impacting C130074G19Rik. C130074G19Rik, orthologous to C1orf115, might be indirectly activated as part of antioxidant pathways. Chlorogenic acid modulates the Keap1-Nrf2 pathway, leading to potential C130074G19Rik activation in structures associated with 9+0 non-motile cilia. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2 influences C130074G19Rik via EP receptors, initiating G protein-coupled signaling. This chemical directly influences prostaglandin pathways, impacting C130074G19Rik activity in structures like non-motile cilia. EP receptor activation induces intracellular cascades, ultimately leading to C130074G19Rik activation and subsequent cellular responses. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
DL-Sulforaphane influences C130074G19Rik through the Keap1-Nrf2 pathway. As a Keap1-Nrf2 activator, it modulates antioxidant responses, potentially impacting C130074G19Rik. C130074G19Rik, located in non-motile cilia, might be indirectly activated as part of antioxidant pathways. Sulforaphane modulates the Keap1-Nrf2 pathway, leading to potential C130074G19Rik activation in structures associated with 9+0 non-motile cilia. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid influences C130074G19Rik through histone deacetylase inhibition. As an HDAC inhibitor, it alters chromatin structure, potentially impacting C130074G19Rik expression. C130074G19Rik, orthologous to C1orf115, might be indirectly activated as part of epigenetic regulation. Valproic acid modulates histone deacetylation, leading to potential C130074G19Rik activation in structures associated with 9+0 non-motile cilia. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
2-Deoxy-D-glucose influences C130074G19Rik through AMP-activated protein kinase (AMPK) activation. As a glycolysis inhibitor, it activates AMPK, potentially impacting C130074G19Rik. C130074G19Rik, located in non-motile cilia, might be indirectly activated as part of cellular energy sensing. 2-Deoxyglucose modulates AMPK activity, leading to potential C130074G19Rik activation in structures associated with 9+0 non-motile cilia. | ||||||