β3 Tubulin Activators
β3 Tubulin activators comprise a diverse group of chemical compounds designed to enhance the activity of β3 tubulin within microtubules, influencing cellular processes reliant on microtubule dynamics. Microtubules, crucial components of the cytoskeleton, play pivotal roles in intracellular transport, cell division, and maintaining cell structure. The activators listed above exert their effects by directly binding to β-tubulin, promoting microtubule stabilization and influencing various cellular processes. Taxol, for instance, stabilizes microtubules by binding to β-tubulin, blocking their depolymerization and promoting tubulin polymerization. This activation of β3 Tubulin leads to enhanced microtubule stability, impacting intracellular transport and mitotic spindle function. Epothilone A and other compounds such as Discodermolide and Peloruside A share a similar mechanism, promoting microtubule stabilization through binding to β-tubulin and influencing cellular processes dependent on microtubule dynamics.
The activation of β3 Tubulin by these compounds is particularly relevant in the context of cancer research and therapy, as microtubules play a critical role in cancer cell proliferation and metastasis. By enhancing microtubule stability, β3 Tubulin activators can impact intracellular transport, disrupt mitotic spindle function, and ultimately inhibit cancer cell division. This class of compounds represents a valuable area of study for understanding and manipulating microtubule dynamics.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Taxol stabilizes microtubules by binding to β-tubulin, inhibiting their depolymerization and promoting tubulin polymerization. This leads to enhanced microtubule stability, impacting cellular processes dependent on microtubule dynamics. Taxol's activation of β3 Tubulin contributes to microtubule stabilization, influencing intracellular transport and mitotic spindle function. | ||||||
Epothilone A | 152044-53-6 | sc-207628 sc-207628A | 10 µg 1 mg | $210.00 $1000.00 | 1 | |
Epothilone A enhances microtubule stability by binding to β-tubulin, promoting tubulin polymerization and preventing depolymerization. This results in stabilized microtubules, impacting cellular processes that rely on microtubule dynamics. Epothilone A's activation of β3 Tubulin contributes to its effects on microtubule stabilization, influencing intracellular transport and mitotic spindle function. | ||||||
Dolastatin 10 | 110417-88-4 | sc-507413 | 5 mg | $980.00 | ||
Dolastatin 10 binds to β-tubulin, promoting microtubule stabilization by inhibiting depolymerization. This results in stabilized microtubules, impacting cellular processes that rely on microtubule dynamics. Dolastatin 10's activation of β3 Tubulin contributes to microtubule stabilization, influencing intracellular transport and mitotic spindle function. | ||||||
Laulimalide | 115268-43-4 | sc-507261 | 100 µg | $200.00 | ||
Laulimalide binds to β-tubulin, promoting microtubule stabilization by inhibiting depolymerization. This results in stabilized microtubules, impacting cellular processes that rely on microtubule dynamics. Laulimalide's activation of β3 Tubulin contributes to microtubule stabilization, influencing intracellular transport and mitotic spindle function. | ||||||
L-Abrine | 526-31-8 | sc-257646 | 250 mg | $212.00 | ||
L-Abrine, an alkaloid, binds to β-tubulin, promoting microtubule stabilization by inhibiting depolymerization. This leads to enhanced microtubule stability, impacting cellular processes dependent on microtubule dynamics. L-Abrine activation of β3 Tubulin contributes to microtubule stabilization, influencing intracellular transport and mitotic spindle function. | ||||||