β3 Tubulin Inhibitors
β3 Tubulin inhibitors belong to a specific chemical class of compounds that interact with and modulate the activity of the β3 isotype of tubulin, which is a structural protein involved in the assembly of microtubules. Microtubules play a crucial role in various cellular processes, including cell division, intracellular transport, and maintenance of cell shape. By selectively targeting β3 tubulin, these inhibitors disrupt microtubule dynamics and function. The binding of β3 tubulin inhibitors to their target leads to alterations in microtubule stability, polymerization, and organization, ultimately impacting cellular processes that rely on the dynamic nature of microtubules.
These compounds' specific mechanism of action distinguishes them from other tubulin-binding agents and offers potential for research purposes in understanding cellular biology and exploring various cellular pathways. Further studies and investigations into the pharmacological properties and cellular effects of β3 tubulin inhibitors could provide valuable insights into the role of microtubules and uncovers new avenues for the development of novel compounds with distinct cellular activities.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine disrupts microtubule dynamics by binding to β-tubulin, preventing polymerization and destabilizing microtubules. This interference inhibits mitotic spindle formation and chromosome segregation, leading to cell cycle arrest. Colchicine's inhibition of β3 Tubulin contributes to disrupted microtubule function and is relevant in cancer research and certain inflammatory conditions. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine inhibits β-tubulin polymerization, disrupting microtubule assembly during mitosis. This disruption hinders the formation of the mitotic spindle, arresting cells in metaphase and inhibiting cell division. Its interference with β3 Tubulin contributes to the destabilization of microtubules, impacting cellular processes and making vinblastine a valuable chemotherapeutic agent against various cancers. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Griseofulvin interferes with microtubule function by binding to β-tubulin, inhibiting microtubule assembly. This disruption affects cell division and the cytoskeleton, impacting various cellular processes. Griseofulvin's interaction with β3 Tubulin contributes to its antifungal properties, making it effective against fungal infections by disrupting the microtubule structure in fungi, impeding their growth and replication. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $84.00 | 1 | |
Podophyllotoxin inhibits β-tubulin polymerization, disrupting microtubule dynamics crucial for mitotic spindle formation. This interference results in cell cycle arrest at metaphase, preventing proper cell division. Podophyllotoxin's impact on β3 Tubulin contributes to its cytotoxic effects, making it a valuable compound in cancer chemotherapy, particularly against tumors where microtubule dynamics play a pivotal role in mitotic processes. | ||||||
Vinorelbine base | 71486-22-1 | sc-205885 sc-205885A sc-205885B sc-205885C sc-205885D | 1 mg 5 mg 25 mg 100 mg 1 g | $29.00 $81.00 $260.00 $791.00 $1977.00 | ||
Vinorelbine interferes with microtubule dynamics by binding to β-tubulin, disrupting mitotic spindle formation. This disruption leads to cell cycle arrest, particularly in the G2/M phase, inhibiting cell division. Vinorelbine's interaction with β3 Tubulin contributes to its antimitotic effects, making it a valuable chemotherapeutic agent against various cancers by targeting microtubule function and impeding cancer cell proliferation. | ||||||
Estramustine | 2998-57-4 | sc-353281 sc-353281A | 100 mg 1 g | $265.00 $743.00 | ||
Estramustine inhibits microtubule assembly by binding to β-tubulin, disrupting mitotic spindle formation and causing cell cycle arrest. This interference impedes cell division and is particularly relevant in cancer research. Estramustine's modulation of β3 Tubulin contributes to its antimitotic effects, making it a compound of interest in prostate cancer therapy, where disruption of microtubule function is a crucial strategy against cancer cell proliferation. | ||||||
Thiocolchicoside | 602-41-5 | sc-202839 sc-202839A | 1 mg 5 mg | $30.00 $120.00 | ||
Thiocolchicoside interferes with microtubule dynamics by binding to β-tubulin, disrupting the assembly of microtubules. This disruption affects cellular processes, particularly those dependent on microtubule function. Thiocolchicoside's interaction with β3 Tubulin contributes to its myorelaxant properties, making it a compound used in muscle relaxant therapies where interference with microtubule dynamics plays a role in mitigating muscle spasms and tension. | ||||||
Combrestatin A4 | 117048-59-6 | sc-204697 sc-204697A | 1 mg 5 mg | $46.00 $81.00 | ||
Combretastatin A-4 (CA-4) disrupts microtubule dynamics by binding to β-tubulin, preventing polymerization and destabilizing microtubules. This interference inhibits mitotic spindle formation and causes cell cycle arrest. | ||||||
Vinflunine | 162652-95-1 | sc-507411 | 10 mg | $390.00 | ||
Vinflunine interferes with microtubule dynamics by binding to β-tubulin, disrupting mitotic spindle formation and causing cell cycle arrest. This interference inhibits cell division, making vinflunine a valuable chemotherapeutic agent. Vinflunine's interaction with β3 Tubulin contributes to its antimitotic effects, specifically targeting cancer cells where disruption of microtubule function is a critical strategy against proliferation and metastasis. | ||||||
Epothilone B, Synthetic | 152044-54-7 | sc-203944 | 2 mg | $176.00 | ||
Epothilone B binds to β-tubulin, promoting microtubule stabilization and preventing depolymerization. This interference with microtubule dynamics leads to mitotic spindle disruption and cell cycle arrest. Epothilone B's interaction with β3 Tubulin contributes to its antimitotic effects, making it a compound of interest in cancer research and therapy, particularly as an alternative to taxanes for targeting microtubules in cancer cells. | ||||||