ARHGAP28 Activators
Rho GTPase Activating Protein 28 (ARHGAP28) is a protein encoded by the ARHGAP28 gene in humans. It belongs to the Rho GTPase-activating protein (RhoGAP) family, which plays a crucial role in regulating the Rho family of GTPases.Rho GTPases are involved in the control of many cellular processes, including cell division, gene expression, and cell migration. They function as molecular switches, alternating between an inactive GDP-bound state and an active GTP-bound state. RhoGAPs, including ARHGAP28, promote the inactive state by stimulating the GTPase activity of Rho proteins, thereby turning off the switch.
ARHGAP28 specifically acts on the RhoA GTPase, a protein involved in the regulation of many cellular activities, including actin cytoskeletal organization, cell cycle progression, and cell migration. By regulating RhoA, ARHGAP28 can influence these processes.In summary, ARHGAP28 is a Rho GTPase-activating protein that plays a critical role in regulating cellular processes by controlling the activity of RhoA GTPase. Future research into the specific functions and implications of ARHGAP28 could provide valuable insights into its roles in health and disease.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Inhibitors of Rho kinase can indirectly modulate ARHGAP28 activity by affecting downstream signaling of Rho GTPases. | ||||||
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $31.00 $89.00 $135.00 $443.00 | 13 | |
Statins can inhibit RhoA activation by blocking its prenylation, potentially influencing pathways involving ARHGAP28. | ||||||
Thymosin β4 | 77591-33-4 | sc-396076 sc-396076A | 1 mg 100 mg | $134.00 $7140.00 | ||
TGF-β1 can modulate Rho GTPase signaling, potentially influencing the activity of ARHGAP28. | ||||||
GW-441756 | 504433-23-2 | sc-200683 sc-200683A | 10 mg 50 mg | $141.00 $565.00 | 3 | |
Rhosin is a selective RhoA inhibitor, which could indirectly impact ARHGAP28 function in the RhoA signaling pathway. | ||||||
GSK 429286 | 864082-47-3 | sc-361200 sc-361200B sc-361200A | 1 mg 5 mg 10 mg | $40.00 $125.00 $235.00 | ||
Inhibitors of ROCK, another downstream effector of Rho GTPases, could indirectly modulate ARHGAP28 activity. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2 can modulate Rho GTPase activity, potentially influencing ARHGAP28-related cellular processes. | ||||||