APBA2BP Activators
APBA2BP Activators represent a class of compounds that influence various intracellular signaling pathways, leading to the functional enhancement of APBA2BP. Compounds like epinephrine, isoproterenol, and terbutaline act as adrenergic receptor agonists, which stimulate adenylyl cyclase resulting in increased cAMP levels. The elevated cAMP activates PKA, which can phosphorylate and enhance the activity of APBA2BP. Similarly, forskolin, a direct activator of adenylyl cyclase, and IBMX, a non-selective inhibitor of phosphodiesterases, also raise cAMP levels, further promoting PKA activity and the subsequent phosphorylation of APBA2BP, thus enhancing its function.
In addition to compounds that raise cAMP levels, other activators like PGE2 and dopamine engage with their respective G-protein-coupled receptors to initiate similar cAMP-PKA signaling cascades, potentially leading to the phosphorylation of APBA2BP. Histamine, through H2 receptor activation, follows the same route of increasing cAMP and activating PKA, which in turn can phosphorylate APBA2BP, leading to its functional enhancement.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
As a hormone and neurotransmitter, epinephrine activates adrenergic receptors which can lead to activation of protein kinase A (PKA). PKA then phosphorylates various proteins including APBA2BP, potentially leading to its enhanced activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, increasing cAMP levels and activating PKA. Activated PKA can phosphorylate APBA2BP, which may increase its functional activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, which increases cAMP levels by preventing its breakdown. The resultant activation of PKA can lead to phosphorylation and activation of APBA2BP. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
This synthetic sympathomimetic amine acts as an agonist for beta-adrenergic receptors, leading to increased cAMP and subsequent activation of PKA. PKA activation can result in enhanced activity of APBA2BP. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram selectively inhibits PDE4, raising cAMP levels in cells, which can enhance PKA-mediated phosphorylation of APBA2BP. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 (PGE2) interacts with its G-protein-coupled receptors, leading to increased cAMP and activation of PKA. PKA then can phosphorylate APBA2BP, thereby enhancing its activity. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine can activate dopamine receptors, particularly D1-like receptors that stimulate adenylyl cyclase, raising cAMP levels and subsequently enhancing PKA activity. This can lead to phosphorylation and activation of APBA2BP. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine, through its H2 receptors, stimulates adenylyl cyclase, increasing cAMP levels and activating PKA. PKA can then enhance APBA2BP activity through phosphorylation. | ||||||
Terbutaline Hemisulfate | 23031-32-5 | sc-204911 sc-204911A | 1 g 5 g | $92.00 $378.00 | 2 | |
Terbutaline acts as a beta-2 adrenergic receptor agonist increasing intracellular cAMP and activating PKA, which in turn may lead to phosphorylation and enhanced activity of APBA2BP. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is known as a JNK activator, and JNK pathway activation can lead to phosphorylation of various proteins. If APBA2BP is a substrate of JNK or its downstream kinases, this could result in enhanced APBA2BP activity. | ||||||