AMPKα1 Activators
AMP-activated protein kinase alpha 1 (AMPKα1) serves as a pivotal regulator of cellular energy homeostasis, orchestrating responses to nutrient availability and metabolic demands. The identified activators of AMPKα1, outlined in the table, act through various mechanisms to enhance its activity. A-769662, for instance, allosterically binds to the β1 subunit, promoting phosphorylation and activation. Metformin, a widely used antidiabetic drug, indirectly activates AMPKα1 by inhibiting mitochondrial complex I, leading to increased cellular AMP levels. AICAR, a direct activator, mimics AMP's effects by promoting AMPKα1 phosphorylation.
Resveratrol and berberine, natural compounds found in red grapes and various plants, respectively, activate AMPKα1 by increasing cellular AMP levels. Dorsomorphin, an inhibitor of BMP type I receptors, indirectly activates AMPKα1, influencing cellular processes like autophagy. GW-6471 indirectly activates AMPKα1 by inhibiting PPARα, shedding light on the crosstalk between signaling pathways. Oligomycin A, by inhibiting mitochondrial ATP synthase, increases cellular AMP levels and triggers AMPKα1 phosphorylation. Phenformin, akin to metformin, activates AMPKα1 by inhibiting mitochondrial complex I. PT-1 and ZLN024, direct activators, bind to AMPKα1's α subunit, promoting phosphorylation and activation. These activators collectively provide a nuanced understanding of AMPKα1 regulation, offering valuable insights into cellular responses governing energy balance and metabolic processes. Researchers can leverage these tools to decipher the intricate roles of AMPKα1 in health and disease, shaping future investigations in cellular and molecular physiology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
A-769662 activates AMPKα1 by allosterically binding to its β1 subunit, promoting phosphorylation and subsequent activation. It enhances AMPKα1's role in energy homeostasis, suppressing hepatic glucose output and promoting fatty acid oxidation through the AMPK signaling pathway. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
Metformin, a widely used antidiabetic drug, activates AMPKα1 indirectly by inhibiting mitochondrial complex I. This leads to an increase in cellular AMP levels, triggering AMPKα1 phosphorylation. Metformin's activation of AMPKα1 helps regulate glucose metabolism and improve insulin sensitivity. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR is a direct activator of AMPKα1 that mimics the effects of AMP. It is phosphorylated to ZMP, which activates AMPKα1 by binding to its γ subunit. This activation promotes glucose uptake and fatty acid oxidation, making AICAR a valuable tool in studying AMPKα1-related cellular processes. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates AMPKα1 by increasing cellular AMP levels and promoting AMPKα1 phosphorylation. This polyphenol, found in red grapes and berries, contributes to AMPKα1-mediated improvements in metabolic parameters, including glucose homeostasis and insulin sensitivity. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine activates AMPKα1 by increasing cellular AMP levels and promoting AMPKα1 phosphorylation. This natural compound, found in various plants, contributes to AMPKα1-mediated improvements in glucose metabolism, making it a potential therapeutic agent for metabolic disorders. | ||||||
GW6471 | 880635-03-0 | sc-300779 | 5 mg | $295.00 | 9 | |
GW-6471 activates AMPKα1 indirectly by inhibiting PPARα, leading to increased cellular AMP levels and AMPKα1 phosphorylation. This activation contributes to the regulation of lipid metabolism and provides insights into the crosstalk between AMPKα1 and PPARα signaling pathways. | ||||||
Phenformin Hydrochloride | 834-28-6 | sc-219590 | 10 g | $119.00 | 4 | |
Phenformin, a biguanide similar to metformin, activates AMPKα1 by inhibiting mitochondrial complex I. This leads to increased cellular AMP levels, triggering AMPKα1 phosphorylation. Phenformin's activation of AMPKα1 contributes to its potential therapeutic effects on metabolic disorders. | ||||||
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $149.00 $12495.00 | 18 | |
Oligomycin A indirectly activates AMPKα1 by inhibiting mitochondrial ATP synthase. This inhibition leads to an increase in cellular AMP levels, triggering AMPKα1 phosphorylation. Oligomycin A provides insights into the regulation of AMPKα1 by mitochondrial ATP production. | ||||||
PT 1 | 331002-70-1 | sc-361299 sc-361299A | 10 mg 50 mg | $185.00 $781.00 | 1 | |
PT-1 activates AMPKα1 by directly binding to its α subunit and promoting phosphorylation. This activation enhances AMPKα1-mediated cellular responses related to energy homeostasis, making PT-1 a valuable tool in studying the specific activation of AMPKα1 and its downstream effects. | ||||||