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ZNRD1 (zinc ribbon domain containing 1), also known as TEX6, Rpa12 or hZR14, is a 126 amino acid protein that localizes to the nucleolus and contains one TFIIS-type zinc finger. Existing as a component of the multi-protein Pol I (RNA polymerase I) complex, ZNRD1 functions as a DNA-dependent RNA polymerase that catalyzes the transcription of DNA into RNA and plays a role in the synthesis of ribosomal RNA (rRNA) precursors. The gene encoding ZNRD1 maps to human chromosome 6, which contains 170 million base pairs and comprises nearly 6% of the human genome. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Additionally, Porphyria cutanea tarda, Parkinson's disease, Stickler syndrome and a susceptibility to bipolar disorder are all associated with genes that map to chromosome 6.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps ZNRD1 (10B7) | sc-135614 | 100 µg/ml | $333.00 |