ZNF276 Antibody (F-10): sc-398207

ZNF276 Antibody (F-10) is a mouse monoclonal IgG2a antibody that detects ZNF276 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ZNF276 is a 614 amino acid protein characterized by five C2H2-type zinc fingers and one zinc finger associated domain, which play a crucial role in its function as a transcriptional regulator. The presence of these zinc finger motifs allows ZNF276 to bind to specific DNA sequences, thereby influencing gene expression and cellular processes. This regulatory capability is particularly important in the context of cancer biology, as ZNF276 has been implicated as a potential tumor suppressor in sporadic breast cancers due to loss of heterozygosity at its chromosomal location. Additionally, the proximity of the ZNF276 gene to the FANCA gene, which encodes a DNA repair protein, suggests a possible interaction that may contribute to the pathogenesis of Fanconi anemia, a genetic disorder characterized by increased cancer susceptibility. Notably, ZNF276 exists in two isoforms resulting from alternative splicing, which may further diversify its functional roles in cellular regulation. Anti-ZNF276 antibody (F-10) is an essential tool for researchers investigating the molecular mechanisms underlying gene regulation and cancer development.

The preferred ZNF276 antibody is ZNF276 Antibody (G-9): sc-373768.